公开(公告)号：EP0673435A1

公开(公告)日：1995-09-27

申请号：EP92919266.0

申请日：1992-08-21

申请人： ISIS PHARMACEUTICALS, INC.

发明人： ECKER, David, J. ,  WYATT, Jacqueline ,  BRUICE, Thomas, W. ,  ANDERSON, Kevin ,  HANECAK, Ronnie, C. ,  VICKERS, Timothy ,  DAVIS, Peter

IPC分类号： C07H21 ,  C12Q1 ,  G01N33

CPC分类号： G01N33/5308 ,  C12Q1/6811 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q1/70 ,  C12Q2537/143

摘要： Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled subunits are provided. The disclosed methods involve repeated syntheses of increasingly simplified sets of oligomers coupled with selection procedures for determining oligomers having the highest activity. Freedom from the use of enzymes allows the application of these methods to any molecules which can be oligomerized in a controlled fashion.