公开(公告)号：EP1648914A2

公开(公告)日：2006-04-26

申请号：EP04780181.6

申请日：2004-07-30

申请人： ISIS PHARMACEUTICALS, INC.

发明人： ESAU, Christine ,  LOLLO, Bridget ,  BENNETT, C., Frank ,  FREIER, Susan, M. ,  GRIFFEY, Richard, H. ,  BAKER, Brenda, F. ,  VICKERS, Timothy ,  MARCUSSON, Eric, G. ,  KOLLER, Erich ,  SWAYZE, Eric, E. ,  JAIN, Ravi ,  BHAT, Balkrishen ,  PERALTA, Eigen

IPC分类号： C07H21/04 ,  A61K48/00

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/3181 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/50 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.

摘要翻译： 化合物，组合物和方法提供了用于调节的小非编码RNA的表达和功能。 所述组合物包含低聚化合物，有针对性的小非编码RNA。 因此，提供了使用这些化合物用于小非编码RNA的调制以及合成的RNA和用于诊断和治疗与小的非编码RNA相关的疾病的下游靶的方法。