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公开(公告)号：EP1416918B1
公开(公告)日：2006-05-31
申请号：EP02734286.4
申请日：2002-05-10
申请人： ISP INVESTMENTS INC.
IPC分类号： A61K9/20
CPC分类号： A61K9/2054 , A61K9/2027
摘要： A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.
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2.发明授权NON-AQUEOUS, HETEROGENEOUS POLYMERIZATION PROCESS AND REACTION PRODUCT OBTAINED THEREBY 有权NOT水性，非均相聚合，从而GOT反应产物
公开(公告)号：EP1037929B1
公开(公告)日：2006-07-12
申请号：EP98958014.7
申请日：1998-11-17
申请人： ISP INVESTMENTS INC.
发明人： PLOCHOCKA, Krystyna , CHUANG, Jui-Chang , SHIH, Jenn, S. , MENON, Anil , NERELLA, Nadhamuni, G.
CPC分类号： A61K8/062 , A61K8/06 , A61K8/064 , A61K8/8141 , A61K9/0014 , A61K47/14 , A61K47/32 , A61K47/44 , A61K2800/57 , A61Q17/04 , A61Q19/00 , C08F2/06 , C08F226/10 , Y10T428/2987 , C08F226/04 , C08F216/125
摘要： A non-aqueous, heterogeneous polymerization process comprises heating a reaction mixture of about 5-70 %, preferably 10-30 %, by weight, of a vinyl monomer in an oil as solvent, and a free radical initiator, optionally in the presence of a crosslinking agent and/or a surfactant, wherein the oil solvent is present in an amount sufficient to keep the resultant polymer in a stirrable state throughout the polymerization. The polymer reaction product is capable of forming a uniform emulsion or gel upon addition of water thereto.
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公开(公告)号：EP1416918A1
公开(公告)日：2004-05-12
申请号：EP02734286.4
申请日：2002-05-10
申请人： ISP INVESTMENTS INC.
CPC分类号： A61K9/2054 , A61K9/2027
摘要： A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.
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4.发明公开CONTROLLED RELEASE DRUG TABLETED COMPOSITION INCLUDING A POLYMER COMBINATION 审中-公开TABLET埃斯特拉达组成药物控释到聚合物上含有的结合
公开(公告)号：EP1047408A1
公开(公告)日：2000-11-02
申请号：EP99901344.4
申请日：1999-01-07
申请人： ISP INVESTMENTS INC.
CPC分类号： A61K9/2027
摘要： A controlled release, drug-delivery tableted composition comprising, by weight, an uncrosslinked or crosslinked polymer of (a) about 5-40 % of a vinyl amide, (b) about 10-70 % of (meth)acrylic acid, (c) about 5-40 % of a long chain alkyl (meth)acrylate or acrylamide, and (d) about 0-60 % of a lower alkyl (meth)acrylate, and a pharmaceutical medicament.
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5.发明公开NON-AQUEOUS, HETEROGENEOUS POLYMERIZATION PROCESS AND REACTION PRODUCT OBTAINED THEREBY 有权NOT水性，非均相聚合，从而GOT反应产物
公开(公告)号：EP1037929A1
公开(公告)日：2000-09-27
申请号：EP98958014.7
申请日：1998-11-17
申请人： ISP INVESTMENTS INC.
发明人： PLOCHOCKA, Krystyna , CHUANG, Jui-Chang , SHIH, Jenn, S. , MENON, Anil , NERELLA, Nadhamuni, G.
CPC分类号： A61K8/062 , A61K8/06 , A61K8/064 , A61K8/8141 , A61K9/0014 , A61K47/14 , A61K47/32 , A61K47/44 , A61K2800/57 , A61Q17/04 , A61Q19/00 , C08F2/06 , C08F226/10 , Y10T428/2987 , C08F226/04 , C08F216/125
摘要： A non-aqueous, heterogeneous polymerization process comprises heating a reaction mixture of about 5-70 %, preferably 10-30 %, by weight, of a vinyl monomer in an oil as solvent, and a free radical initiator, optionally in the presence of a crosslinking agent and/or a surfactant, wherein the oil solvent is present in an amount sufficient to keep the resultant polymer in a stirrable state throughout the polymerization. The polymer reaction product is capable of forming a uniform emulsion or gel upon addition of water thereto.
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