公开(公告)号：EP3595731A1

公开(公告)日：2020-01-22

申请号：EP18709043.6

申请日：2018-03-13

申请人： International Centre For Genetic Engineering And Biotechnology - ICGEB

发明人： GIACCA, Mauro ,  BRAGA, Luca ,  DAL FERRO, Matteo ,  CUNHA MANO, Miguel Luis ,  BREGIEIRO EULALIO, Ana Sofia

IPC分类号： A61K48/00 ,  C12N5/077 ,  C12N15/113

公开(公告)号：EP4421173A1

公开(公告)日：2024-08-28

申请号：EP23158617.3

申请日：2023-02-24

申请人： International Centre For Genetic Engineering And Biotechnology - ICGEB

发明人： BRAGA, Luca ,  VOLPE, Maria Concetta

IPC分类号： C12N15/11 ,  A61P11/00

CPC分类号： A61P11/00 ,  C12N2310/14120130101 ,  C12N15/113

摘要： The present invention refers to an agent for use in the prevention and/or treatment of lung pathological conditions associated with loss of alveolar epithelial type II and/or type I cells and/or with loss of lung regenerative capacity and/or for use in promoting lung regeneration in a subject with a lung condition, said agent being selected from the group consisting of: hsa-miR-124-3p, hsa-miR-5008-5p, hsa-miR-4255, hsa-miR-4691-5p, hsa-miR-4781-5p,h sa-miR-4782-5p, hsa-miR-3928-3p , inhibitor of hsa-miR-183-3p, inhibitor of hsa-miR-16-2-3p, inhibitor of hsa-mir-147b-3p and inhibitor of hsa-miR-1292-3p or a combination thereof.