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公开(公告)号：EP3472160A1
公开(公告)日：2019-04-24
申请号：EP17732059.5
申请日：2017-06-15
发明人： BERTHELOT, Didier, Jean-Claude , MEVELLEC, Laurence, Anne , ANGIBAUD, Patrick, René , COUPA, Sophie , DEMESTRE, Christophe, Gabriel, Marcel , MEERPOEL, Lieven , MERCEY, Guillaume, Jean, Maurice , MEYER, Christophe , PASQUIER, Elisabeth, Thérèse, Jeanne , PILATTE, Isabelle, Noëlle, Constance , PONCELET, Virginie, Sophie , QUEROLLE, Olivier, Alexis, Georges
IPC分类号： C07D471/04 , C07D487/04 , A61K31/496 , A61P35/00
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公开(公告)号：EP3233862A1
公开(公告)日：2017-10-25
申请号：EP15810784.7
申请日：2015-12-18
发明人： MEVELLEC, Laurence, Anne , MEERPOEL, Lieven , COUPA, Sophie , PONCELET, Virginie, Sophie , PILATTE, Isabelle, Noëlle, Constance , PASQUIER, Elisabeth, Thérèse, Jeanne , BERTHELOT, Didier, Jean-Claude , QUEROLLE, Olivier, Alexis, Georges , MEYER, Christophe , ANGIBAUD, Patrick, René , DEMESTRE, Christophe, Gabriel, Marcel , MERCEY, Guillaume, Jean, Maurice
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及式（I）的取代的咪唑并哒嗪衍生物，其中各变量具有权利要求书中定义的含义。 根据本发明的化合物可用作p13Kβ抑制剂。 本发明进一步涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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3.发明公开SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AND 5,6,7,8-TETRAHYDRO-4H-PYRAZOLO[1,5-A][1,4]DIAZEPINE DERIVATIVES AS ROS1 INHIBITORS 审中-公开取代基4,5,6,7-四氢吡喃并[1,5-a]吡啶并[1,5-a]吡啶并[1,5-a] [1,4]二氮杂萘衍生物 ROS1抑制剂
公开(公告)号：EP3129376A1
公开(公告)日：2017-02-15
申请号：EP15713436.2
申请日：2015-03-26
发明人： MEVELLEC, Laurence, Anne , PASQUIER, Elisabeth, Thérèse, Jeanne , DESCAMPS, Sophie , MERCEY, Guillaume, Jean, Maurice , WROBLOWSKI, Berthold , VIALARD, Jorge, Eduardo , MEERPOEL, Lieven , JEANTY, Matthieu, Ludovic , JOUSSEAUME, Thierry, François, Alain, Jean
IPC分类号： C07D487/04 , A61K31/519 , A61K35/00
CPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , C07B59/002 , C07B2200/05 , C07D487/10 , C07D487/20 , C07D519/00 , C07F9/6561
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as ROS1 inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及取代的4,5,6,7-四氢 - 吡唑并[1,5-a]吡嗪衍生物和5,6,7,8-四氢-4H-吡唑并[1,5-a] [1， 4]式（I）的二氮杂衍生物，其中变量具有权利要求中限定的含义。 根据本发明的化合物可用作ROS 1抑制剂。 本发明还涉及制备这些新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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