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1.发明公开DUAL ANTIGEN-INDUCED BIPARTITE FUNCTIONAL COMPLEMENTATION 有权DUALE ANTIGEN-INDUZIERTE ZWEITEILIGE FUNKICKALE KOMPLEMENTIERUNG
公开(公告)号：EP2802607A2
公开(公告)日：2014-11-19
申请号：EP13704369.1
申请日：2013-01-14
发明人： STUHLER, Gernot
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2833 , C07K16/289 , C07K16/3061 , C07K16/468 , C07K2317/34 , C07K2317/56 , G01N33/574
摘要： The present invention relates to a set of polypeptides and its uses. In particular, the present invention relates to a set of polypeptides whereby this set comprises two polypeptides each of which comprises a targeting moiety "T" binding to an antigen "A" and a fragment of "F" of a functional domain, wherein said two polypeptides are not associated with each other in absence of a substrate that has "A" at (on) its surface and wherein, upon dimerization of "F", the resulting dimer becomes functional. Furthermore, medical and diagnostic uses of said set are described. Moreover, the present invention relates to nucleic acid molecule(s) encoding said set of polypeptides. The present invention also relates to a vector comprising the nucleotide sequence of nucleic acid molecule(s) encoding said set of polypeptides. Furthermore, the present invention relates to pharmaceutical compositions comprising said set of polypeptides. Moreover, the present invention relates to a kit comprising said set of polypeptides.
摘要翻译： 本发明涉及一组多肽及其用途。 特别地，本发明涉及一组多肽，其中该组包含两个多肽，每个多肽包含结合抗原“A”的靶向部分“T”和功能结构域的“F”的片段，其中所述两个 多肽在不存在其表面上（上）具有“A”的底物时彼此不相关，并且其中在“F”二聚时，所得二聚体变得功能性。 此外，描述了所述组的医疗和诊断用途。 此外，本发明涉及编码所述多肽多肽的核酸分子。 本发明还涉及包含编码所述多肽组的核酸分子的核苷酸序列的载体。 此外，本发明涉及包含所述多肽组合物的药物组合物。 此外，本发明涉及包含所述多肽组的试剂盒。
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公开(公告)号：EP2802607B1
公开(公告)日：2017-10-04
申请号：EP13704369.1
申请日：2013-01-14
发明人： STUHLER, Gernot
IPC分类号： C07K16/28 , C07K16/30 , C07K16/46 , A61K39/00 , G01N33/574
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2833 , C07K16/289 , C07K16/3061 , C07K16/468 , C07K2317/34 , C07K2317/56 , G01N33/574
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公开(公告)号：EP3907241A1
公开(公告)日：2021-11-10
申请号：EP21174675.5
申请日：2013-01-14
发明人： STUHLER, Gernot
IPC分类号： C07K16/28 , C07K16/30 , C07K16/46 , A61P1/04 , A61P3/10 , A61P9/00 , A61P7/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K16/32 , G01N33/574
摘要： The present invention relates to a set of polypeptides and its uses. In particular, the present invention relates to a set of polypeptides whereby this set comprises two polypeptides each of which comprises a targeting moiety "T" binding to an antigen "A" and a fragment of "F" of a functional domain, wherein said two polypeptides are not associated with each other in absence of a substrate that has "A" at (on) its surface and wherein, upon dimerization of "F", the resulting dimer becomes functional. Furthermore, medical and diagnostic uses of said set are described. Moreover, the present invention relates to nucleic acid molecule(s) encoding said set of polypeptides. The present invention also relates to a vector comprising the nucleotide sequence of nucleic acid molecule(s) encoding said set of polypeptides. Furthermore, the present invention relates to pharmaceutical compositions comprising said set of polypeptides. Moreover, the present invention relates to a kit comprising said set of polypeptides.
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公开(公告)号：EP4346885A1
公开(公告)日：2024-04-10
申请号：EP22732043.9
申请日：2022-05-27
发明人： STUHLER, Gernot , SCHNYDER, Tim , NOWOTNY, Boris , BREMER, Annika
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公开(公告)号：EP3333190A1
公开(公告)日：2018-06-13
申请号：EP17193746.9
申请日：2013-01-14
发明人： STUHLER, Gernot
IPC分类号： C07K16/28 , C07K16/30 , C07K16/46 , G01N33/574 , A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2833 , C07K16/289 , C07K16/3061 , C07K16/468 , C07K2317/34 , C07K2317/56 , G01N33/574
摘要： The present invention relates to a set of polypeptides and its uses. In particular, the present invention relates to a set of polypeptides whereby this set comprises two polypeptides each of which comprises a targeting moiety "T" binding to an antigen "A" and a fragment of "F" of a functional domain, wherein said two polypeptides are not associated with each other in absence of a substrate that has "A" at (on) its surface and wherein, upon dimerization of "F", the resulting dimer becomes functional. Furthermore, medical and diagnostic uses of said set are described. Moreover, the present invention relates to nucleic acid molecule(s) encoding said set of polypeptides. The present invention also relates to a vector comprising the nucleotide sequence of nucleic acid molecule(s) encoding said set of polypeptides. Furthermore, the present invention relates to pharmaceutical compositions comprising said set of polypeptides. Moreover, the present invention relates to a kit comprising said set of polypeptides.
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6.发明公开RECOMBINANT ANTIBODY MOLECULE AND ITS USE FOR TARGET CELL RESTRICTED T CELL ACTIVATION 审中-公开重组抗体分子及其使用的靶细胞LIMITED T细胞活化
公开(公告)号：EP3180361A1
公开(公告)日：2017-06-21
申请号：EP15757154.8
申请日：2015-08-11
CPC分类号： C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2896 , C07K16/30 , C07K16/3053 , C07K16/468 , C07K2317/31 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2319/00
摘要： The present disclosure relates to a recombinant antibody molecule, bispecific as well as tri-specific hetero-dimeric antibody molecules, as well as a method for producing the same, its use and a nucleic acid molecule encoding the recombinant antibody molecules. The disclosure in particular provides an antibody molecule that is capable of mediating target cell restricted activation of immune cells.
摘要翻译： 本发明涉及一种重组抗体分子，双特异性以及三特异性杂二聚体抗体分子，以及其制造方法，其用途和编码重组抗体分子的核酸分子的方法。 特别是本发明提供了对抗体分子确实能够介导的免疫细胞的靶细胞限制性活化。
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