公开(公告)号：EP0336713B1

公开(公告)日：1992-12-16

申请号：EP89303321.7

申请日：1989-04-04

申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

发明人： Itoh, Kunio ,  Sugiyama, Kiyoshi ,  Ohta, Motohiro

IPC分类号： A61K9/52 ,  A23K1/18

CPC分类号： A61K9/5047 ,  A23K40/35 ,  A61K9/5015 ,  A61K9/5026 ,  Y10S426/807

公开(公告)号：EP0336713A3

公开(公告)日：1990-01-24

申请号：EP89303321.7

申请日：1989-04-04

申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

发明人： Itoh, Kunio ,  Sugiyama, Kiyoshi ,  Ohta, Motohiro

IPC分类号： A61K9/52 ,  A23K1/18

CPC分类号： A61K9/5047 ,  A23K40/35 ,  A61K9/5015 ,  A61K9/5026 ,  Y10S426/807

摘要： A coating agent for delaying the release of a physiologically active substance to be administered per os to ruminants, comprising a veterinarially acceptable water-soluble, synthetic high molecular compound and ethylcellulose, said coating agent being stable in the first stomach of ruminants and capable of being effectively disintegrated in the fourth stomach of ruminants, characterized in that said coating agent further comprises at least one substance which is miscible with both of said high molecular weight compound and ethylcellulose and is insoluble in water. The coating agent protects the active substance from degradation in the first stomach of a ruminant at a pH of about 5.5 and rapidly breaks down in the fourth stomach at a pH of about 3, so releasing the active ingredient for absorption by the animal.

公开(公告)号：EP0336713A2

公开(公告)日：1989-10-11

申请号：EP89303321.7

申请日：1989-04-04

申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

发明人： Itoh, Kunio ,  Sugiyama, Kiyoshi ,  Ohta, Motohiro

IPC分类号： A61K9/52 ,  A23K1/18

CPC分类号： A61K9/5047 ,  A23K40/35 ,  A61K9/5015 ,  A61K9/5026 ,  Y10S426/807

摘要： A coating agent for delaying the release of a physiologically active substance to be administered per os to ruminants, comprising a veterinarially acceptable water-soluble, synthetic high molecular compound and ethylcellulose, said coating agent being stable in the first stomach of ruminants and capable of being effectively disintegrated in the fourth stomach of ruminants, characterized in that said coating agent further comprises at least one substance which is miscible with both of said high molecular weight compound and ethylcellulose and is insoluble in water.
The coating agent protects the active substance from degradation in the first stomach of a ruminant at a pH of about 5.5 and rapidly breaks down in the fourth stomach at a pH of about 3, so releasing the active ingredient for absorption by the animal.

摘要翻译： 一种用于延迟每个口服给药的生理活性物质释放到包含兽医学上可接受的水溶性合成高分子化合物和乙基纤维素的反刍动物的包衣剂，所述包衣剂在反刍动物的第一胃中是稳定的并且能够被 在反刍动物的第四胃中有效地分解，其特征在于所述包衣剂还包含至少一种与所述高分子量化合物和乙基纤维素可混溶并且不溶于水的物质。 包衣剂在约5.5的pH下保护活性物质在反刍动物的第一胃中不会降解，并且在约3的pH下在第四胃中快速分解，因此释放活性成分以供动物吸收。