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公开(公告)号：EP3215157B1
公开(公告)日：2019-04-10
申请号：EP15795317.5
申请日：2015-11-06
发明人： BEEHARRY, Neil , GAYLE, Sophia , LANDRETTE, Sean , BECKETT, Paul , CONRAD, Chris , XU, Tian , ROTHBERG, Jonathan M. , LICHENSTEIN, Henri
IPC分类号： A61K31/5377 , A61K45/06 , A61P35/00 , A61K31/437 , G01N33/574
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公开(公告)号：EP3215157A1
公开(公告)日：2017-09-13
申请号：EP15795317.5
申请日：2015-11-06
发明人： BEEHARRY, Neil , GAYLE, Sophia , LANDRETTE, Sean , BECKETT, Paul , CONRAD, Chris , XU, Tian , ROTHBERG, Jonathan M. , LICHENSTEIN, Henri
IPC分类号： A61K31/5377 , A61K45/06 , A61P35/00 , A61K31/437
CPC分类号： A61K31/5377 , A61K9/0019 , A61K31/437 , A61K31/44 , A61K45/06 , G01N33/5743 , G01N2800/52 , A61K2300/00
摘要： The present invention relates to methods for treating melanoma with apilimod and related compositions and methods.
摘要翻译： 本发明涉及用阿维莫德和相关组合物和方法治疗结肠直肠癌的方法。
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公开(公告)号：EP3253389A1
公开(公告)日：2017-12-13
申请号：EP16747116.8
申请日：2016-02-02
IPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/34
CPC分类号： A61K31/5377 , A61K9/0019 , A61K31/404 , A61K31/4178 , A61K31/439 , A61K31/473 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods for treating Charcot-Marie-Tooth Disease (CMT) with apilimod and related compositions and methods.
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公开(公告)号：EP3104891A1
公开(公告)日：2016-12-21
申请号：EP15706986.5
申请日：2015-02-10
IPC分类号： A61K47/00 , A61K9/00 , A61K9/12 , A61K31/436 , A61K31/70
CPC分类号： A61K31/436 , A61K9/0075 , A61K9/12 , A61K9/145 , A61K31/138 , A61K31/366 , A61K31/4196 , A61K31/506 , A61K31/517 , A61K45/06 , A61K47/00 , A61M15/0021 , A61M15/003 , A61M15/0045 , A61M2202/064 , A61K2300/00
摘要： The present invention relates to methods and compositions for treating lymphangioleiomyomatosis in a human subject in need of such treatment. The methods comprise administering to the subject via inhalation an aerosol composition comprising rapamycin or a prodrug or derivative (including analog) thereof.
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公开(公告)号：EP3215159A1
公开(公告)日：2017-09-13
申请号：EP15795319.1
申请日：2015-11-06
发明人： BEEHARRY, Neil , GAYLE, Sophia , LANDRETTE, Sean , BECKETT, Paul , CONRAD, Chris , XU, Tian , HERNANDEZ, Marylens , ROTHBERG, Jonathan M. , LICHENSTEIN, Henri
IPC分类号： A61K31/5377 , A61K45/06 , A61P35/00 , A61K31/437 , A61K31/44 , G01N33/50
CPC分类号： A61K31/5377 , A61K9/0019 , A61K31/437 , A61K31/44 , A61K45/06 , G01N33/5743 , G01N2800/52 , A61K2300/00
摘要： The present invention relates to methods for treating colorectal cancer with apilimod and related compositions and methods.
摘要翻译： 本发明涉及用阿维莫德和相关组合物和方法治疗结肠直肠癌的方法。
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6.发明公开AN INHALABLE RAPAMYCIN FORMULATION FOR THE TREATMENT OF PULMONARY HYPERTENSION 审中-公开一种不可避免的雷帕霉素制剂治疗肺高血压
公开(公告)号：EP3209330A1
公开(公告)日：2017-08-30
申请号：EP15787076.7
申请日：2015-10-07
IPC分类号： A61K45/06 , A61K9/00 , A61K31/436 , A61K31/557 , A61P9/12 , A61P11/00 , A61K9/12
CPC分类号： A61K31/436 , A61K9/0075 , A61K9/12 , A61K9/1617 , A61K9/1623 , A61K31/557 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods and compositions for the treatment and prophylaxis of pulmonary arterial hypertension (PAH) in a human subject in need of such treatment, the methods comprising the pulmonary administration to the subject, preferably via inhalation of a composition comprising rapamycin or a prodrug or derivative thereof.
摘要翻译： 本发明涉及用于治疗和预防需要这种治疗的人类受试者中的肺动脉高压（PAH）的方法和组合物，所述方法包括向受试者肺部施用，优选通过吸入包含雷帕霉素或 前药或衍生物。
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