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    Dispersible cimetidine tablets
    2.
    发明公开
    Dispersible cimetidine tablets 失效
    Dispergierbare，Cimetidin enthaltende Tabletten。

    公开(公告)号：EP0347767A1

    公开(公告)日：1989-12-27

    申请号：EP89110951.4

    申请日：1989-06-16

    申请人： LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.

    发明人： Kovacic, Mateja ,  Milovac, Jenny ,  Cvelbar, Polona ,  Stalc, Anton ,  Trost, Zvezdana ,  Kopitar, Zdravko ,  Kofler, Bojan ,  Nikolic, Vida ,  Lampret, Marija ,  Lippai, Marija

    IPC分类号： A61K31/415 ,  A61K9/20

    CPC分类号： A61K31/415 ,  A61K9/2004 ,  A61K9/2013 ,  A61K9/2031

    摘要： There are described novel dispersible cimetidine tablets containing 30 to 90 % by weight of one of the polymorphous modifications of cimetidine A, B or C, 5 to 55 % by weight of one or more disintegrationg agents, 0.05 to 5.0 % by weight of a surfactant, such as sodium lauryl sulphate together with other common adjuvants.
    The process for the manufacture of dispersible cimetidine tablets is effected on the basis of known methods by granulating the ingredients and by compressing the granu­late to tablets.
    Dispersible tablets disintegrate when brought in contact with water at room tempera­ture within less than 1 minute to yield a fine dispersion, which facilitates the oral ap­plication. Therefore such tablets are particularly suitable for certain groups of patients, especiallly for the aged and children. Dispersible tablets containing cimetidine excell by their improved rate of dissolution and good bioavailability.

    摘要翻译： 描述了含有30至90重量％的西咪替丁A，B或C的多晶型修饰之一，5至55重量％的一种或多种崩解剂，0.05至5.0重量％的表面活性剂 ，如十二烷基硫酸钠以及其他常见佐剂。 基于已知方法制备分散西咪替丁片的方法是通过造粒成分并将颗粒压制成片剂而实现的。 当在小于1分钟内在室温下与水接触时，可分散的片剂产生细分散体，这有利于口服。 因此，这种片剂特别适用于某些患者群体，特别适合于老年人和儿童。 含有西咪替丁的分散片优于其改善的溶解速率和良好的生物利用度。