公开(公告)号：EP2729164A4

公开(公告)日：2015-05-06

申请号：EP12807609

申请日：2012-07-06

申请人： LFB USA INC

发明人： EVANS SEAN A ,  ALLARD GREG J ,  MASIELLO NICHOLAS C

IPC分类号： A61K9/08 ,  A61K38/57 ,  A61K47/02

CPC分类号： A61K47/02 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/57

摘要： In one aspect, the disclosure provides formulations that stabilize proteins, wherein the formulations comprise a buffer. In some embodiments, the buffer comprises potassium mono-hydrogen-phosphate and potassium di-hydrogen-phosphate, or the buffer comprises sodium mono-hydrogen-phosphate and sodium di-hydrogen-phosphate. In some embodiments, the protein is a therapeutic protein. In some embodiments, the therapeutic protein is antithrombin.