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公开(公告)号：EP1368296A1
公开(公告)日：2003-12-10
申请号：EP02725147.9
申请日：2002-03-12
发明人： BELL, Michael, Gregory , GRESE, Timothy, Alan , GERNERT, Doug, Linn , YUMIBE, Nathan, P. , BOEHM, Marcus, F. , MICHELLYS, Pierre-Yves , ARDECKY, Robert, J. , MAPES, Christopher, M. , CHEN, Jyun-Hung , TYHONAS, John, S.
IPC分类号： C07C59/64 , A61K31/192 , A61P3/00 , A61P17/00
CPC分类号： C07C59/64
摘要： The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.
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公开(公告)号：EP1216221A2
公开(公告)日：2002-06-26
申请号：EP00965088.8
申请日：2000-09-14
发明人： ARDECKY, Robert, J. , BOEHM, Marcus F. , FAULKNER, Amy, L. , HAMANN, Lawrence, G. , JONES, Todd, K. , MAPES, Christopher, M. , MICHELLYS, Pierre-Yves , TYHONAS, John, S. , THOMPSON, Anthony, J. , CHEN, Jyun-Hung
IPC分类号： C07C59/64 , C07C59/72 , C07D333/24 , C07D307/54 , C07D213/55 , C07C37/055 , C07C41/52 , C07C45/29 , C07C47/277 , C07C67/343 , C07C69/734 , A61K31/203 , A61P17/06 , A61P9/00 , A61P17/10 , A61P5/14
CPC分类号： C07D333/24 , C07C59/64 , C07C59/72 , C07D213/55 , C07D307/54
摘要： The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently claimed modulators. The present invention also provides synthetic methods for preparing these compounds as well as pharmaceutical compositions incorporating these novel compounds and methods for the therapeutic use of such compounds and pharmaceutical compositions.
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