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1.发明授权TRANSDERMALES THERAPEUTISCHES SYSTEM FÜR FLÜCHTIGE UND/ODER THERMOLABILE STOFFE 有权透皮治疗系统中挥发性和/或材料不耐热
公开(公告)号：EP1971328B1
公开(公告)日：2016-06-08
申请号：EP06829676.3
申请日：2006-12-16
发明人： JUNG, Tobias , HORSTMANN, Michael , DZEKAN, Horst
IPC分类号： A61K9/70 , A61K31/465 , A61F13/02
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7084
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2.发明公开WIRKSTOFFPARTIKELHALTIGES TRANSDERMALES THERAPEUTISCHES SYSTEM MIT ERHÖHTEM WIRKSTOFFFLUSS 无效活性颗粒含透皮治疗系统，具有增强的主动流动
公开(公告)号：EP2029121A1
公开(公告)日：2009-03-04
申请号：EP07725656.8
申请日：2007-05-30
IPC分类号： A61K9/70
CPC分类号： A61K9/7069 , A61K9/7092
摘要： The invention relates to a transdermal therapeutic system, preferably as transdermal patch, which has an active ingredient-containing matrix which consists substantially of a water-insoluble base material such as, for example, rubber and synthetic polymers, into which water-soluble and/or water-swellable inclusion bodies, e.g. composed of polyvinyl alcohol or polyethylene glycol, which comprise micronized or nanoscale active ingredient particles are incorporated.
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3.发明公开TRANSDERMALES THERAPEUTISCHES SYSTEM FÜR 5-AMINOLÄVULINSÄUREHYDROCHLORID 有权转铁蛋白治疗系统FÜR5-AMINOLÄVULINSÄUREHYDROCHLORID
公开(公告)号：EP2750673A1
公开(公告)日：2014-07-09
申请号：EP12750597.2
申请日：2012-08-24
发明人： JUNG, Tobias , HORSTMANN, Michael , HOFFMANN, Gerd
IPC分类号： A61K31/197 , A61K9/70
CPC分类号： A61K9/7061 , A61K31/195 , A61K31/197
摘要： The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.
摘要翻译： 本发明涉及一种透皮治疗系统，其包括对活性成分不可渗透的背层，含有活性成分的聚合物基质和可被拉出的保护层，其中使用5-氨基乙酰丙酸盐酸盐作为活性成分 成分和聚合物基质的基本聚合物是粘合剂聚丙烯酸酯。 所述透皮治疗系统适用于诊断和治疗皮肤癌的初期阶段，如光化性角化病和肿瘤性皮肤病。
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4.发明授权TRANSDERMALES THERAPEUTISCHES SYSTEM FÜR 5-AMINOLÄVULINSÄUREHYDROCHLORID 有权TRANSDERMALES THERAPEUTISCHES SYSTEMFÜR5-AMINOLVELINSÄULHYDROCHLORID
公开(公告)号：EP2750673B1
公开(公告)日：2017-08-09
申请号：EP12750597.2
申请日：2012-08-24
发明人： JUNG, Tobias , HORSTMANN, Michael , HOFFMANN, Gerd
IPC分类号： A61K9/70 , A61K31/197
CPC分类号： A61K9/7061 , A61K31/195 , A61K31/197
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5.发明授权WIRKSTOFFPARTIKELHALTIGES TRANSDERMALES THERAPEUTISCHES SYSTEM MIT ERHÖHTEM WIRKSTOFFFLUSS 无效活性颗粒含透皮治疗系统，具有增强的主动流动
公开(公告)号：EP2029121B1
公开(公告)日：2010-03-03
申请号：EP07725656.8
申请日：2007-05-30
IPC分类号： A61K9/70
CPC分类号： A61K9/7069 , A61K9/7092
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6.发明公开TRANSDERMALES THERAPEUTISCHES SYSTEM FÜR FLÜCHTIGE UND/ODER THERMOLABILE STOFFE 有权透皮治疗系统中挥发性和/或材料不耐热
公开(公告)号：EP1971328A1
公开(公告)日：2008-09-24
申请号：EP06829676.3
申请日：2006-12-16
发明人： JUNG, Tobias , HORSTMANN, Michael , DZEKAN, Horst
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7084
摘要： The present invention relates to a transdermal therapeutic system comprising at least one readily volatile and/or thermolabile active ingredient and/or auxiliary, which can be produced by laminating at least three components onto one another, namely a polymeric matrix layer, a likewise polymeric acceptor layer that absorbs the active ingredient and/or auxiliary at an increased rate, and a donor layer comprising, at the point of production, the volatile and/or thermolabile active ingredient and/or auxiliary. The system according to the invention is characterized in that, during or shortly after the lamination process, the donor layer combines with the acceptor layer as a result of migration of the readily volatile and/or thermolabile substances.
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