公开(公告)号：EP1968578A2

公开(公告)日：2008-09-17

申请号：EP06832241.1

申请日：2006-12-14

申请人： MAKHTESHIM CHEMICAL WORKS LIMITED

发明人： ZAMIR, Sharona

IPC分类号： A61K31/4152

CPC分类号： C07D231/44 ,  A01N43/56 ,  A01N47/02 ,  C07B2200/13 ,  C07C15/06 ,  C07C49/203

摘要： The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.

公开(公告)号：EP2307388A2

公开(公告)日：2011-04-13

申请号：EP09766320.7

申请日：2009-06-17

申请人： MAKHTESHIM CHEMICAL WORKS LIMITED

发明人： ZAMIR, Sharona ,  MASON, Doron ,  FAKTOROVITCH, Inna

IPC分类号： C07D249/12 ,  A01N43/653

CPC分类号： C07D249/12

摘要： There is disclosed a crystalline DMSO solvate of prothioconazole as well as amorphous prothioconazole. Methods for making these solid forms, microbicidal compositions comprising them and uses thereof are also disclosed.

公开(公告)号：EP2129221A2

公开(公告)日：2009-12-09

申请号：EP08702644.9

申请日：2008-01-16

申请人： MAKHTESHIM CHEMICAL WORKS LIMITED

发明人： ZAMIR, Sharona ,  FAKTOROVITCH, Inna

IPC分类号： A01N43/54 ,  C07D239/52

CPC分类号： C07D239/52 ,  A01N43/54

摘要： The present invention relates to novel crystalline polymorphic and amorphous forms of the compound methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylate (azoxystrobin). Infrared Raman spectra, X-ray powder diffraction pattern and differential scanning calorimetry thermogram of two polymorphs "A" and "B" are provided. Further, the present invention also provides methods for preparing the novel polymorphic forms "A" and "B", as well as processes for producing mixtures of the polymorphs, and a process for preparing amorphous azoxystrobin. Yet further, the present invention provides anti-fungal compositions comprising the novel crystalline polymorphs "A" and "B" or amorphous azoxystrobin, which are useful for controlling and combating fungi grown on agricultural and horticultural crops and up-land, and methods of using the same as pesticidal agents for combating fungi on agricultural and horticultural crops.

摘要翻译： 本发明涉及化合物甲基（E）-2- {2- [6-（2-氰基苯氧基）嘧啶-4-基氧基]苯基} -3-甲氧基 - 丙烯酸酯（嘧菌酯）的新型结晶多晶型和无定形形式。 提供了两种多晶型物“A”和“B”的红外拉曼光谱，X射线粉末衍射图和差示扫描量热法。 此外，本发明还提供了制备新型多晶型“A”和“B”的方法，以及制备多晶型物的混合物的方法，以及制备无定形嘧菌酯的方法。 此外，本发明提供了包含新型结晶多晶型物“A”和“B”或无定形嘧菌酯的抗真菌组合物，其可用于控制和对抗在农业和园艺作物和陆地上生长的真菌，以及使用方法 与农业和园艺作物上的杀真菌剂相同。

公开(公告)号：EP1954271A2

公开(公告)日：2008-08-13

申请号：EP06821571.4

申请日：2006-11-23

申请人： MAKHTESHIM CHEMICAL WORKS LIMITED

发明人： COHEN, Shlomi ,  ZAMIR, Sharona

IPC分类号： A61K31/44

CPC分类号： C07D213/74

摘要： The present invention relates to an improved process for the synthesis and purification of 3-chloro-N-(3-chloro-5-trifluoromethyl-2-pyridyl)-a,a,a-trifluoro-2,6-dinitro-p-toluidine (fluazinam) and other pyridinamines, which implements methyl isobutyl ketone (MIBK) as the reaction solvent. The process of the invention overcomes the drawbacks of prior art methods, by reducing the side reactions such as hydrolysis, eliminating the need for difficult and labor-intensive purification methods, and providing pure products in higher yields. The present invention relates to novel crystalline polymorphic forms fluazinam, and to mixtures of the polymorphs. The present invention also provides methods for preparing the novel polymorphs, as well as pharmaceutical compositions comprising same, and methods of using the polymorphs as pesticidal agents for combating noxious living organisms on agricultural and horticultural crops.