公开(公告)号：EP0660722A1

公开(公告)日：1995-07-05

申请号：EP91915301.0

申请日：1991-07-03

申请人： MALLINCKRODT MEDICAL, INC.

发明人： WOLFANGEL, Robert, F.

IPC分类号： A61K51

CPC分类号： A61K51/1093 ,  A61K51/1241 ,  A61K2121/00 ,  A61K2123/00

摘要： A method of preparing a stable, therapeutic radiopharmaceutical composition comprised of an alpha- or beta-emitting radionuclide and a ligand by lyophilizing a solution of the complex. The radionuclide preferably has a half-life of at least twelve hours. The invention also is directed to stable lyophilized radiopharmaceutical compositions prepared by this method. The invention is particularly suited to the preparation of radionuclide-labeled antibodies in a stable form which merely requires reconstitution at the point of use.