-
1.发明公开
公开(公告)号：EP1644532A4
公开(公告)日：2007-11-28
申请号：EP04777309
申请日：2004-06-30
IPC分类号： C12Q1/68 , A61B20060101 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
-
2.发明公开TARGETS, METHODS, AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA 审中-公开目标，方法和试剂用于治疗精神分裂症的诊断与治疗
公开(公告)号：EP1578354A4
公开(公告)日：2008-04-09
申请号：EP03728301
申请日：2003-03-26
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156
-
公开(公告)号：EP2968317A4
公开(公告)日：2016-12-28
申请号：EP14762460
申请日：2014-03-17
申请人： UNIV COLUMBIA
发明人： KARAYIORGOU MARIA , MARKX SANDER , GOGOS JOSEPH A
IPC分类号： A61K31/497 , A61K31/4745 , A61K31/519 , A61K31/5377 , A61P25/00 , A61P25/18 , A61P25/24 , C07D471/04
CPC分类号： A61K31/519 , A61K31/4745 , A61K31/5377
-
4.发明公开INHIBITOR OF NEURONAL CONNECTIVITY LINKED TO SCHIZOPHRENIA SUSCEPTIBILITY AND COGNITIVE DYSFUNCTION 有权含有精神分裂症可能性和认知功能障碍的神经连接抑制剂
公开(公告)号：EP2726108A4
公开(公告)日：2014-11-26
申请号：EP12805368
申请日：2012-06-29
申请人： UNIV COLUMBIA
发明人： GOGOS JOSEPH A , XU BIN , KARAYIORGOU MARIA
IPC分类号： A61K48/00 , A61K38/17 , C07K14/435 , C07K14/47 , C12N15/11 , C12N15/113 , G01N33/68
CPC分类号： C07K14/435 , A61K38/1709 , C07K14/4703 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/141 , G01N33/6896 , C12N2330/10 , C12N2310/531
摘要： The present invention relates to methods and compositions for enhancing neuronal connectivity. It is based, at least in part, on the discovery of a protein, termed “Mirta22,” that inhibits the formation of structures which create connections between neurons. It is further based, in part, on the discovery that inhibiting Mirta22 activity by short hairpin RNA was able to restore these structures. Mirta22 was discovered in experiments relating to 22q11 microdeletions, which have been linked to schizophrenia. Accordingly, the present invention provides for methods of treating schizophrenia comprising administering an agent that inhibits Mirta22 activity. It may also be used in the treatment of other disorders that would benefit from enhanced neural connectivity, including learning and memory disorders.
-
-
-
搜索结果
4 条记录 (耗时 0.011 秒)
