公开(公告)号：EP1313455A2

公开(公告)日：2003-05-28

申请号：EP01980290.9

申请日：2001-08-28

申请人： Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V.

发明人： ANTIPOV, Alexei ,  VIEIRA, Euridice ,  IBARZ, Gemma ,  SUKHORUKOV, Gleb ,  DÄHNE, Lars ,  GAO, Changyou ,  DONATH, Edwin ,  MÖHWALD, Helmuth

IPC分类号： A61K9/52 ,  B01J13/02

CPC分类号： A61K9/5073 ,  B01J13/20

摘要： Method of layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes was applied to coat fluorescein particles. These particles with a size of 4-9 νm were prepared by precipitation of fluorescein at pH 2. Polysterensulfonate (PSS) and polyallylamine (PAH) were used to compose the polyelectrolyte shell on the fluorescein core. The release of fluorescein molecules through the polyelectrolyte shell core dissolution was monitored at pH 8 by increasing fluorescence intensity. The number of polyelectrolyte layers sufficient to sustain fluorescence release was found to be 8-10. Sequentially adsorbed layers prolong core dissolution time for minutes. The permeability of polyelectrolyte multilayers of the thickness of 20 nm is about 10-8 m/s. Mechanism of fluorescence diffusion and osmotically supported release is under discussion. The features of release profile and possible applications of LbL method for shell formation in order to control release properties for entrapped materials are outlined. Also ambient conditions of pH, temperature and salt concentration were changed to control the permeability of polyelectrolyte multilayer capsules.

公开(公告)号：EP1305109A1

公开(公告)日：2003-05-02

申请号：EP01969563.4

申请日：2001-08-01

申请人： Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V.

发明人： VOIGT, Andreas ,  SUKHORUKOV, Gleb ,  RADTCHENKO, Igor ,  ANTIPOV, Alexei ,  DONATH, Edwin ,  MÖHWALD, Helmuth

IPC分类号： B01J13/02 ,  B01J13/10 ,  B01J13/22

CPC分类号： A61K9/5192 ,  A61K9/5026 ,  A61K9/5089 ,  A61K9/5138 ,  B01J13/02 ,  B01J13/10 ,  B01J13/22 ,  Y10T428/2984

摘要： The invention relates to a method for producing nano or microcapsules comprising a polyelectrolyte casing, by surface precipitation from the solution, by applying a casing to the template particles. The inventive method comprises the following steps: (a) providing a dispersion of template particles having a suitable size in a saline liquid phase that contains the components required for producing the casing dissolved therein, and (b) precipitating the components from the liquid phase onto the template particles under conditions enabling the production of a casing around the template particles that has a thickness of from 1 to 100 nm.

摘要翻译： 本发明涉及通过向模板颗粒施加套层，通过从溶液中表面沉淀，生产包含聚电解质套管的纳米或微胶囊的方法。 本发明的方法包括以下步骤：（a）提供在盐水液相中具有合适尺寸的模板颗粒的分散体，所述盐水液体相包含生产溶解于其中的外壳所需的组分，和（b）将组分从液相沉淀到 模板颗粒在能够在模板颗粒周围产生厚度为1至100nm的套管的条件下进行。

公开(公告)号：EP1307282A1

公开(公告)日：2003-05-07

申请号：EP01971841.0

申请日：2001-08-01

申请人： Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V.

发明人： VOIGT, Andreas ,  SUKHORUKOV, Gleb ,  ANTIPOV, Alexei ,  DONATH, Edwin ,  MÖHWALD, Helmuth ,  SEIBT, Horst

IPC分类号： B01J13/02 ,  B01J13/10 ,  B01J13/22

CPC分类号： A61K9/5192 ,  A61K9/5026 ,  A61K9/5089 ,  A61K9/5138 ,  B01J13/02 ,  B01J13/10 ,  B01J13/22 ,  Y10T428/2984

摘要： The invention relates to a method for applying a shell to liquid template particles, comprising the following steps: (a) preparation of an emulsion of liquid template particles in a continuous liquid or gel phase, whereby at least one amphiphilic polyelectrolyte or polyelectrolyte complex, or a copolymer of charged hydrophilic monomers and oil soluble monomers is dissolved in the fluid template particles and/or the continuous phase and a film is formed at the phase boundary between the liquid template particle and the continuous phase and (b) application of a shell to the film formed at the phase boundary.