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    ANTIBODIES AND CYCLIC PEPTIDES WHICH BIND CEA (CARCINOEMBRYONIC ANTIGEN) AND THEIR USE AS CANCER THERAPEUTICS
    1.
    发明公开
    ANTIBODIES AND CYCLIC PEPTIDES WHICH BIND CEA (CARCINOEMBRYONIC ANTIGEN) AND THEIR USE AS CANCER THERAPEUTICS 审中-公开
    抗体和环肽的CEA（“癌胚抗原”）结合位及其作为癌症治疗剂

    公开(公告)号：EP1554309A2

    公开(公告)日：2005-07-20

    申请号：EP03769082.3

    申请日：2003-10-03

    申请人： McGILL UNIVERSITY

    发明人： STANNERS, Clifford, P. ,  ILANTZIS, Christian

    IPC分类号： C07K14/705 ,  C07K16/30 ,  C07K16/28

    CPC分类号： C07K16/3007 ,  A61K2039/505 ,  C07K2317/55

    摘要： The present invention relates to differentiation and tumorigenicity. The present invention more particularly relates to ligands which target CEA and CEACAM6 such that the adhesion, differentiation-Inhibitory activities and tumorigenic effects of Ig superfamily members, CEA and CEACAM6, can be reduced or blocked. More particularly, the present invention relates to CEA-binding agents which reverse CEA-mediated tumorigenic effects by declustering CEA and CEACAM6. In one embodiment the invention relates to methods of reducing, preventing or reversing a CEA-mediated tumorigenic effect comprising a use of a CEA-mediated tumorigenic effect reducing CEA-declustering agent. In one embodiment, the invention relates to compositions and use thereof for reversing CEA-mediated tumorigenic effects on human cancer cells and uses thereof. In particular, the application relates to a monovalent CEA binding agent which interfereswith a CEA interaction responsible for a CEA-mediated tumorigenic effects, thereby minimizing or reversing same.