公开(公告)号：EP1250441A1

公开(公告)日：2002-10-23

申请号：EP01911543.5

申请日：2001-01-27

申请人： Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung

发明人： HOFMANN, Kay ,  CONRADT, Marcus

IPC分类号： C12N15/55 ,  C12N9/80 ,  C12N5/10 ,  C12Q1/68 ,  C12Q1/44 ,  A61P17/00 ,  A61K38/50 ,  A61K7/48 ,  A61K48/00 ,  A01K67/027

CPC分类号： C12N9/80 ,  A01K2217/05 ,  A61K38/00

摘要： The invention relates to ceramidase having the following structural motif Z1-X1-H-X2-T-L-X2-X2-X2-X2-Q-X2-X2-D-E-Z2, wherein the X1 position represents an aromatic amino acid (F, Y or W), all X2 positions represent any independent amino acids, and Z?1 and Z2¿ are any polypeptides.

公开(公告)号：EP1204757A1

公开(公告)日：2002-05-15

申请号：EP00956442.8

申请日：2000-08-12

申请人： Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung

发明人： HOFMANN, Kay

IPC分类号： C12N15/55 ,  C12N9/16 ,  C12N5/10 ,  C07K16/40 ,  G01N33/50 ,  A61K38/43 ,  A01K67/027

CPC分类号： C12N9/16 ,  A01K2217/05 ,  A01K2217/075

摘要： Nucleic acids which code for eucaryontic neutral cerebral-sphingomyelinase n (nSMase2) have the following sequence motifs: X1-X2-X3-X4-D-Y-X5 and X6-X7-T-D-H-X8, whereby X1, X6 = A or G; X2, X3 = R or K; X4, X5, X7, X8 = I or L or V or M.