公开(公告)号：EP2063710A2

公开(公告)日：2009-06-03

申请号：EP07837578.9

申请日：2007-08-31

申请人： Merck & Co., Inc.

发明人： STANTON, Matthew, G. ,  MUNOZ, Benito ,  SLOMAN, David, L. ,  HUBBS, Jed ,  HAMBLETT, Christopher

IPC分类号： A01N43/40 ,  A61K31/435 ,  C07D211/34

CPC分类号： C07D211/38

摘要： Compounds of formula (I). Selectively inhibit production of Aβ(1-42) and hence find use in treatment of diseases associated with deposition of β-amyloid in the brain.

公开(公告)号：EP2120584A1

公开(公告)日：2009-11-25

申请号：EP07853393.2

申请日：2007-12-14

申请人： Merck & Co., Inc.

发明人： MUNOZ, Benito ,  HUBBS, Jed ,  HAMBLETT, Christopher, L. ,  ZHOU, Hua ,  MARTINEZ, Michelle

IPC分类号： A01N55/00 ,  A61K31/695

CPC分类号： C07F7/0812

摘要： Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of Aß(1-42) and hence find use in treatment of Alzheimer's disease and related conditions.