公开(公告)号：EP1893608A2

公开(公告)日：2008-03-05

申请号：EP05858618.1

申请日：2005-10-06

申请人： Merck and Co., Inc.

发明人： COSFORD, Nicholas, D. ,  SEIDERS, Thomas, J. ,  PAYNE, Joseph ,  ROPPE, Jeffrey, R. ,  HUANG, Dehua ,  SMITH, Nicholas, D. ,  POON, Steve, F. ,  KING, Chris ,  EASTMAN, Brian, W. ,  WANG, Bowei ,  ARRUDA, Jeannie, M. ,  VERNIER, Jean-Michel ,  ZHAO, Xiumin

IPC分类号： C07D417/00

CPC分类号： C07D417/06 ,  C07D417/14 ,  C07D471/04

摘要： The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts.