专利检索 ap:("Merck AND Co., Inc." OR "The Regents of the University of Colorado") AND inv:"BUNN, Paul" 第 1 页

1.

发明公开
METHODS OF USING SAHA AND ERLOTINIB FOR TREATING CANCER 审中-公开
标题翻译：使用方法SAHA和厄洛替尼治疗癌症

公开(公告)号：EP1942907A2

公开(公告)日：2008-07-16

申请号：EP06836951.1

申请日：2006-11-03

申请人： Merck and Co., Inc. , The Regents of the University of Colorado

发明人： BUNN, Paul , WITTA, Samir , RICHON, Victoria, M. , FRANKEL, Stanley , DEUTSCH, Paul , RANDOLPH, Sophia

IPC分类号： A61K31/70

CPC分类号： A61K31/167 , A61K31/19 , A61K31/517 , A61K2300/00

摘要： The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor such as suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of one or more anti-cancer agents, including Erlotinib. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.