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    Processes and intermediates for preparing fused heterocyclic kinase inhibitors
    2.
    发明公开
    Processes and intermediates for preparing fused heterocyclic kinase inhibitors 有权
    Verfahren und Zwischenverbindungen zur Herstellung kondensierter heterolischer Kinase-Hemmer

    公开(公告)号：EP2426108A1

    公开(公告)日：2012-03-07

    申请号：EP11009425.7

    申请日：2008-08-29

    申请人： MethylGene Inc.

    发明人： Raeppel, Franck ,  Isakovic, Ljubomir ,  Claridge, Stephen, William ,  Mannion, Michael ,  Zhan, Lijie ,  Granger, Marie-Claude ,  Vaisburg, Arkadii ,  Nantel, Miguel

    IPC分类号： C07D213/61 ,  C07D495/04

    CPC分类号： C07D495/04 ,  C07D213/38 ,  C07D213/51 ,  C07D213/61

    摘要： The invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, particularly at an industrial level. The processes are aimed at ultimately forming compounds of the formula (A) where M is thieno[3,2,b]pyridinyl as shown, the group D is a ring or ring system, preferably pyridine, and the group Z, Ar, and G are as defined herein. Such compounds can act to inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling.

    摘要翻译： 本发明涉及制备稠合杂环型激酶抑制剂化合物如噻吩并吡啶类化合物的方法和中间体，以及用于制备可用于制备稠合杂环型激酶抑制剂化合物的中间体的方法和中间体，特别是在 工业水平。 所述方法目的在于最终形成式（A）化合物，其中M为噻吩并[3,2，b]吡啶基，如D所示，基团D为环或环系，优选吡啶，Z，Ar和 G如本文所定义。 这些化合物可以起到抑制生长因子受体的蛋白酪氨酸激酶活性的作用，导致受体信号传导的抑制，例如VEGF受体信号传导和HGF受体信号传导的抑制。