公开(公告)号：EP1177445B1

公开(公告)日：2007-07-11

申请号：EP00928860.6

申请日：2000-05-05

申请人： NEUROGEN CORPORATION

发明人： TALLMAN, John ,  GALLAGER, Dorothy ,  SHAW, Kenneth ,  WHITE, Geoffrey ,  CRANDALL, Marci ,  CASSELLA, James ,  RAJACHANDRAN, Lavanya ,  ALBAUGH, Pamela

IPC分类号： G01N33/566 ,  G01N33/94

CPC分类号： G01N33/9426 ,  G01N2333/70571 ,  G01N2500/00

摘要： Methods are provided that are useful in assaying compounds for cognitive enhancing properties, anxiolytic properties, hypnotic properties, or antidepressant properties. These methods involve determining the in vitro efficacy and EC50 of the compounds at defined series of cloned GABAA subtype receptors composed of specific variants of alpha , beta , and gamma subunits in order to develop and an activity profile for each compound. Optionally, the binding affinities of the compounds at GABAA receptors are also determined. As an additional step the in vivo effects of the compounds may be tested in animal models.

公开(公告)号：EP1177445A1

公开(公告)日：2002-02-06

申请号：EP00928860.6

申请日：2000-05-05

申请人： NEUROGEN CORPORATION

发明人： TALLMAN, John ,  GALLAGER, Dorothy ,  SHAW, Kenneth ,  WHITE, Geoffrey ,  CRANDALL, Marci ,  CASSELLA, James ,  RAJACHANDRAN, Lavanya ,  ALBAUGH, Pamela

IPC分类号： G01N33/566 ,  G01N33/94

CPC分类号： G01N33/9426 ,  G01N2333/70571 ,  G01N2500/00

摘要： Methods are provided that are useful in assaying compounds for cognitive enhancing properties, anxiolytic properties, hypnotic properties, or antidepressant properties. These methods involve determining the in vitro efficacy and EC50 of the compounds at defined series of cloned GABAA subtype receptors composed of specific variants of α,β, and η subunits in order to develop and an activity profile for each compound. Optionally, the binding affinities of the compounds at GABAA receptors are also determined. As an additional step the in vivo effects of the compounds may be tested in animal models.