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    DOUBLE-STRANDED LIPID-MODIFIED RNA HAVING HIGH RNA INTERFERENCE EFFECT
    2.
    发明公开
    DOUBLE-STRANDED LIPID-MODIFIED RNA HAVING HIGH RNA INTERFERENCE EFFECT 有权
    DOPPELSTRÄNGIGE脂质变性RNA麻醉HOHEM RNA-INTERFERENZEFFEKT

    公开(公告)号：EP2264167A1

    公开(公告)日：2010-12-22

    申请号：EP09729165.2

    申请日：2009-03-31

    申请人： National Institute of Advanced Industrial Science and Technology ,  Otsuka Pharmaceutical Co., Ltd. ,  Hayashi Kasei Co., Ltd.

    发明人： KUBO, Takanori ,  OHBA, Hideki ,  TOYOBUKU, Hidekazu ,  HAYASHI, Hirotake

    IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K48/00

    CPC分类号： C12N15/111 ,  C12N2310/3515 ,  C12N2320/32

    摘要： An object of the present invention is to provide a novel double-stranded RNA that has high resistance to nuclease and cellular uptake efficiency and that can produce an excellent RNA interference effect. The present invention provides a double-stranded lipid-modified RNA comprising a sense strand having a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand having a nucleotide sequence complementary to the sense strand, the double-stranded RNA being capable of suppressing the expression of the target gene, and the sense strand having a double-stranded lipid bound directly or via a linker to at least one of the first to sixth nucleotides from the 5' end.

    摘要翻译： 本发明的目的是提供对核酸酶和细胞摄取效率具有高抗性并且可以产生优异的RNA干扰效果的新型双链RNA。 本发明提供了包含具有与靶基因中的靶序列互补的核苷酸序列的有义链和具有与有义链互补的核苷酸序列的反义链的双链脂质修饰的RNA，所述双链RNA为 能够抑制靶基因的表达，并且具有直链或经由连接体结合至5'末端的至少一个第一至第六个核苷酸的双链脂质的有义链。