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1.发明授权SUBSTITUTED CAPROLACTAM CARBONATES AND ETHERS AND THEIR USE AS ANTI-TUMOR AGENTS 有权取代碳酸己内酰胺和乙醚及其用途抗肿瘤活性
公开(公告)号：EP1282604B1
公开(公告)日：2008-01-09
申请号：EP01975824.2
申请日：2001-05-09
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D223/12 , A61K31/55 , A61P35/00
CPC分类号： C07D223/12
摘要： The present invention relates to certain substituted caporlactam carbonate and ether compounds of following formula (I): pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.
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2.发明公开
公开(公告)号：EP1682181A2
公开(公告)日：2006-07-26
申请号：EP04765542.8
申请日：2004-09-23
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , BRUEGGEN, Josef, Bernhard , HUANG, Jerry, Min-Jian , KINDER, Frederick, Ray, Jr. , LANE, Heidi , LATOUR, Elisabeth, Jeanne , MANLEY, Paul, William , WOOD, Jeanette, Marjorie
IPC分类号： A61K45/06 , A61K31/502
CPC分类号： A61K45/06 , A61K31/502 , A61K2300/00
摘要： The present invention relates to a combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis. The patient is treated with a VEGF inhibitor compound; and one or more chemotherapeutic agents.
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3.发明授权
公开(公告)号：EP1131297B1
公开(公告)日：2004-04-14
申请号：EP99957309.0
申请日：1999-11-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： KINDER, Frederick, Ray, Jr. , BAIR, Kenneth, Walter , JAGOE, Christopher, Turchik , VERSACE, Richard, William , WATTANASIN, Sompong
IPC分类号： C07D223/10 , C07D409/12 , C07D403/12 , C07D401/12 , A61K31/55 , A61P35/00
CPC分类号： C07D401/12 , C07D223/10 , C07D403/12 , C07D409/12
摘要： The present invention relates to certain substituted caprolactam compounds of formula (I), where R1 is (C1-6)alkyl or (C3-6)cycloalkyl; R2 is hydrogen or (C1-6)alkyl; X is (C1-12)alkylene; (C2-12)alkenylene; or (C2-12)alkynylene; m is 0 or 1; and R3 is (C3-8)cycloalkyl; or an aromatic ring system selected from (II, III, IV and V), where R4 is hydrogen, chloro, or methoxy; R5 is hydrogen, chloro, (C1-18)alkyl or (C1-18)alkoxy, and Z is oxygen, sulfur, N-H, or N-CH3; or a pharmaceutically acceptable acid addition salt thereof, where possible, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.
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公开(公告)号：EP1651633A1
公开(公告)日：2006-05-03
申请号：EP04763455.5
申请日：2004-07-23
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： C07D401/06 , C07D223/12 , A61K31/55 , A61P35/00
CPC分类号： C07D401/06 , C07D223/12
摘要： This invention relates to certain substituted lactam compounds of the formula (I), particularly caprolactam compounds, which are useful for the treatment of cancer.
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5.发明公开CERTAIN SUBSTITUTED POLYKETIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN TREATING TUMORS 审中-公开某些取代聚酮化合物含药物组合物及其用于肿瘤的治疗
公开(公告)号：EP1417195A1
公开(公告)日：2004-05-12
申请号：EP02794555.9
申请日：2002-08-05
申请人： Novartis AG , Novartis Pharma GmbH
发明人： KINDER, Frederick, Ray, Jr. , BAIR, Kenneth, Walter , RAMSEY, Timothy, Michael , SABIO, Michael, Lloyd
IPC分类号： C07D309/30 , C07C271/12
CPC分类号： C07D309/30
摘要： The present invention relates to certain substituted polyketides of formula (I), wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.
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6.发明公开CERTAIN SALTS OF DISCODERMOLIDE ACID, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN TREATING TUMORS 审中-公开迪莫利德？酸的某些盐，含药物组合物及它们在肿瘤的治疗
公开(公告)号：EP1381591A2
公开(公告)日：2004-01-21
申请号：EP02742902.6
申请日：2002-04-16
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07C271/12 , A61K31/27 , A61P35/00
CPC分类号： C07C271/12 , C07B2200/07
摘要： The present invention relates to discodermolidate acid salts of formula (I) where R is as defined herein, pharmaceutical compositions containing said salts, the use of said salts alone or in combination with other therapeutic agents in treating tumors and to a process for making said salts.
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7.发明公开SUBSTITUTED CAPROLACTAM CARBONATES AND ETHERS AND THEIR USE AS ANTI-TUMOR AGENTS 有权取代碳酸己内酰胺和乙醚及其用途抗肿瘤活性
公开(公告)号：EP1282604A1
公开(公告)日：2003-02-12
申请号：EP01975824.2
申请日：2001-05-09
IPC分类号： C07D223/12 , A61K31/55 , A61P35/00
CPC分类号： C07D223/12
摘要： The present invention relates to certain substituted caporlactam carbonate and ether compounds of following formula (I): pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.
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8.发明公开
公开(公告)号：EP1131297A1
公开(公告)日：2001-09-12
申请号：EP99957309.0
申请日：1999-11-15
发明人： KINDER, Frederick, Ray, Jr. , BAIR, Kenneth, Walter , JAGOE, Christopher, Turchik , VERSACE, Richard, William , WATTANASIN, Sompong
IPC分类号： C07D223/10 , C07D409/12 , C07D403/12 , C07D401/12 , A61K31/55 , A61P35/00
CPC分类号： C07D401/12 , C07D223/10 , C07D403/12 , C07D409/12
摘要： The present invention relates to certain substituted caprolactam compounds of formula (I), where R1 is (C1-6)alkyl or (C3-6)cycloalkyl; R2 is hydrogen or (C1-6)alkyl; X is (C1-12)alkylene; (C2-12)alkenylene; or (C2-12)alkynylene; m is 0 or 1; and R3 is (C3-8)cycloalkyl; or an aromatic ring system selected from (II, III, IV and V), where R4 is hydrogen, chloro, or methoxy; R5 is hydrogen, chloro, (C1-18)alkyl or (C1-18)alkoxy, and Z is oxygen, sulfur, N-H, or N-CH3; or a pharmaceutically acceptable acid addition salt thereof, where possible, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.
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