公开(公告)号：EP1670807A1

公开(公告)日：2006-06-21

申请号：EP04765669.9

申请日：2004-09-28

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BILLICH, Andreas ,  ETTMAYER, Peter ,  MECHTCHERIAKOVA, Diana ,  NUSSBAUMER, Peter ,  WLACHOS, Alexander

IPC分类号： C07F9/113 ,  C07C215/24 ,  C09B69/00 ,  C12N9/12

CPC分类号： C12N9/1205 ,  C07C219/20 ,  C07C233/71 ,  C07C237/08 ,  C07C237/10 ,  C07C311/41 ,  C07C2603/50 ,  C07D271/12 ,  C07F9/65324 ,  C12Q1/42 ,  C12Q1/485 ,  G01N2500/02

摘要： The present invention relates to a method (assay) for determining the activity of an enzyme selected from the group consisting of a sphingosine kinase and a phosphatase involved in the sphingolipid pathway by use of a labeled sphingosine.

摘要翻译： 本发明涉及一种用于通过使用标记的鞘氨醇来测定选自鞘氨醇激酶和参与神经鞘脂途径的磷酸酶的酶的活性的方法（测定）。

公开(公告)号：EP2081649A2

公开(公告)日：2009-07-29

申请号：EP07821129.9

申请日：2007-10-10

申请人： NOVARTIS AG

发明人： BAUMRUKER, Thomas ,  BILLICH, Andreas ,  MECHTCHERIAKOVA, Diana ,  WLACHOS, Alexander

IPC分类号： A61P37/02 ,  A61K39/00 ,  A61K48/00

CPC分类号： G01N33/564 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/285 ,  G01N2800/52

摘要： The use of CD1 B, or CD1 D, respectively as a target for a disorder selected from Systemic Lupus Erythematosus (SLE), Lupus Anticoagulant (LA) Rheumatoid Arthritis (RA) and Idiopathic Thrombocytopenic Purpura, and the use of CD1 D as a target in a disorder which is Multiple Sclerosis (MS), e g as a biomarker, a method for preparing a diagnostic kit and a method for identifying agents that modulates a disorder which is mediated by elevated levels of CD1 B, or CD1 D, respectively, in case of CD1 B, or CD1 D, respectively selected from Systemic Lupus Erythematosus (SLE), Lupus Anticoagulant (LA) Rheumatoid Arthritis (RA) and Idiopathic Thrombocytopenic Purpura, and in case of CD1 D a disorder which is Multiple Sclerosis (MS)