公开(公告)号：EP0485530A4

公开(公告)日：1993-04-28

申请号：EP90915235

申请日：1990-09-10

申请人： ONCOGEN LIMITED PARTNERSHIP ,  MATRIX PHARMACEUTICAL INC.

发明人： BROWN, DENNIS, M. ,  LUCK, EDWARD ,  TWARDZIK, DANIEL, R. ,  PURCHIO, ANTHONY, F.

IPC分类号： A61K31/135 ,  A61K9/00 ,  A61K38/00 ,  A61K38/17 ,  A61K38/18 ,  A61K47/42 ,  A61K47/48 ,  A61P35/00 ,  C07K14/00 ,  C07K14/435 ,  C07K14/495 ,  C07K14/52 ,  C07K17/04 ,  C07K15/00

CPC分类号： A61K9/0024 ,  A61K38/1841 ,  A61K47/42 ,  A61K47/642

摘要： Antiproliferative compositions are provided which are capable of sustained release of an antiproliferative agent, particularly a TGF- beta , at a site proximal to a target cell. The compositions are effective in inhibiting proliferation of the target cell, particularly when used in combination with a vasoconstrictive agent.