公开(公告)号：EP1685832B1

公开(公告)日：2011-04-06

申请号：EP04792173.9

申请日：2004-10-01

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： TATEISHI, Narito ,  YAMAMOTO, Junki, Ono Pharmaceutical Co., Ltd. ,  KAWAHARADA, Soichi, Ono Pharmaceutical Co., Ltd. ,  AKIYAMA, Tsutomu, Ono Pharmaceutical Co., Ltd. ,  HOSHIKAWA, Masamitsu, Ono Pharmaceutical Co., Ltd.

IPC分类号： A61K31/19 ,  A61K31/20 ,  A61P9/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00

CPC分类号： A61K31/20 ,  A61K31/19 ,  A61K45/06

摘要： Nerve regeneration promoters containing compounds represented by the following general formula (1), salts thereof or prodrugs of the same: (1) wherein each symbol is as defined in the specification. The compounds represented by the general formula (1) inhibit nerve cell death and promote the formation of new nerve cells and nerve cell regeneration and also promote the repair and regeneration of nerve tissues and functions through neurite extension, because of serving as a stem cell (nerve stem cell, embryonic stem cell, bone marrow cell, etc.) proliferation/differentiation promoter, a nerve cell precursor proliferation/differentiation promoter, a neurotrophic factor activity enhancer, a neurotrophic factor-like substance or a neurodegeneration inhibitor. Furthermore, these compounds are useful in preparing cells for transplantation (nerve stem cells, nerve cell precursors, nerve cells, etc.) from a brain tissue, bone marrow, embryonic stem cells, etc. At the same time, these compounds promote the take, proliferation, differentiation and function expression of transplanted cells, which makes them useful as preventives and/or remedies for neurodegenerative diseases.

公开(公告)号：EP1685832A1

公开(公告)日：2006-08-02

申请号：EP04792173.9

申请日：2004-10-01

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： TATEISHI, Narito, Ono Pharmaceutical Co., Ltd. ,  YAMAMOTO, Junki, Ono Pharmaceutical Co., Ltd. ,  KAWAHARADA, Soichi, Ono Pharmaceutical Co., Ltd. ,  AKIYAMA, Tsutomu, Ono Pharmaceutical Co., Ltd. ,  HOSHIKAWA, Masamitsu, Ono Pharmaceutical Co., Ltd.

IPC分类号： A61K31/19 ,  A61K31/20 ,  A61K45/00 ,  C12N5/06 ,  A61P9/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/20 ,  A61K31/19 ,  A61K45/06

摘要： A nerve regeneration which comprises a compound is represented by formula (I):

(wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases.

摘要翻译： 包含化合物的神经再生由式（I）表示：（其中所有符号在说明书中显示），其盐或其前药。 本发明的化合物抑制作为加速生长和/或分化的干细胞（神经干细胞，胚胎干细胞，骨髓细胞等）的生长和/或分化的物质的神经细胞死亡 的神经前体细胞，神经营养因子活性的增强剂，神经营养因子样物质或神经变性抑制剂，并通过新生，再生和/或轴突进化加速神经组织的修复和再生。 此外，本发明的化合物可用于从用于移植的细胞（神经干细胞，神经前体细胞，神经细胞等）的脑组织，骨髓和/或胚胎干细胞制备，并且还加速接枝，生长 ，用于移植的细胞的分化和/或功能表达，因此它可用于预防和/或治疗神经变性疾病。