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公开(公告)号:EP0894087A2
公开(公告)日:1999-02-03
申请号:EP97914347.0
申请日:1997-03-27
发明人: TIMMERBACKA, Mika , LEHTONEN, Jorma , TANNINEN, Veli, Pekka , MUTTONEN, Esa , KAUKONEN, Jukka , HYPPÖLÄ, Riikka , BÄCKSTRÖM, Reijo
CPC分类号: C07D237/04
摘要: A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is described. The end product is useful as a cardiotonic agent. A novel crystalline polymorphic form of the end product is also described.
摘要翻译: ( - ) - [[4-(1,4,5,6-四氢-4-甲基-6-氧代-3-哒嗪基)苯基]亚肼基]丙二腈的外消旋6-(4- 氨基苯基)-4,5-二氢-5-甲基-3(2H) - 哒嗪酮中间体。 最终产品可用作强心剂。 还描述了最终产品的新颖结晶多晶型形式。