公开(公告)号：EP1181036A4

公开(公告)日：2004-04-21

申请号：EP00921929

申请日：2000-04-07

申请人： ORTHO MCNEIL PHARM INC

发明人： CHEUNG WING K ,  NATARAJAN JAYA ,  SANDERS MARILYN ,  VERCAMEN ELS ,  SHARMA BASANT ,  BEGUN SELIMA

IPC分类号： A61K47/04 ,  A61K9/00 ,  A61K38/18 ,  A61K38/22 ,  A61K47/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/26 ,  A61K47/42 ,  A61P7/06 ,  A61P7/08 ,  A61K38/16

CPC分类号： A61K9/0019 ,  A61K38/1816 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61K47/42

摘要： The present invention provides aqueous pharmaceutical formulations of erythropoietin that are free of human serum blood products, stabilized with a quantity of an amino acid and a sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) derivative. The present invention also provides aqueous stable, preserved pharmaceutical formulations of erythropoietin that contain an antimicrobial quantity of cresol and a quantity of an amino acid.