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    NUCLEIC ACID SEQUENCING METHODS AND SYSTEMS
    2.
    发明公开
    NUCLEIC ACID SEQUENCING METHODS AND SYSTEMS 审中-公开

    公开(公告)号：EP3325642A1

    公开(公告)日：2018-05-30

    申请号：EP15745338.2

    申请日：2015-07-21

    申请人： Omniome, Inc.

    发明人： VIJAYAN, Kandaswamy ,  TU, Eugene ,  BERNARD, Mark A.

    IPC分类号： C12Q1/68

    摘要： The present disclosure provides compositions, methods and systems for sequencing a template nucleic acid using a polymerase based, nucleic acid binding reaction involving examination of the interaction between a polymerase and template nucleic acid in the presence of one or more unlabeled nucleotides. The methods rely, in part, on identifying a base of a template nucleic acid during nucleic acid synthesis by controlling the sequencing reaction conditions. Template nucleic acid bases may be identified during an examination step followed by an optional incorporation step.