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1.发明公开NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis 失效（2S，3S）-3-（2-甲氧基苄基氨基）-2-苯基哌啶在Kombination mit Ondansetron zur Behandlung von Emesis
公开(公告)号：EP0715855A2
公开(公告)日：1996-06-12
申请号：EP95308273.2
申请日：1995-11-20
申请人： PFIZER INC.
发明人： Gonsalves, Susan F.
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , Y10S514/816 , Y10S514/872
摘要： The present invention relates to a method of treating or preventing emesis in a mammal, including a human, by administering to the mammal a 5HT 3 receptor antagonist and an NK-1 receptor antagonist ( e.g. , a substance P receptor antagonist). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a 5HT 3 receptor antagonist and an NK-1 receptor antagonist.
摘要翻译： 本发明涉及通过向哺乳动物施用5HT3受体拮抗剂和NK-1受体拮抗剂（例如物质P受体拮抗剂）来治疗或预防包括人在内的哺乳动物的呕吐的方法。 它还涉及含有药学上可接受的载体，5HT3受体拮抗剂和NK-1受体拮抗剂的药物组合物。
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2.发明公开Antiemetic composition containing an NK-1 receptor antagonists 失效抗菌药Arzneimittel，das NK-1 Rezeptor-Antagonistenenthält
公开(公告)号：EP0769300A2
公开(公告)日：1997-04-23
申请号：EP96307533.8
申请日：1996-10-17
申请人： PFIZER INC.
IPC分类号： A61K45/06
CPC分类号： A61K45/06
摘要： The present invention relates to methods of treating or preventing emesis in mammals, including humans, using an NK-1 antagonist in combination with one or more other active agents selected from (a) a glucocorticoid or corticosteroid, (b) a benzodiazepine, (c) metaclopramide and (d) an intracellular molecular scavenger.
摘要翻译： 本发明涉及使用NK-1拮抗剂与选自（a）糖皮质激素或皮质类固醇的一种或多种其它活性剂联合治疗或预防包括人在内的哺乳动物的呕吐的方法，（b）苯并二氮杂 ）氯氨酰氯和（d）细胞内分子清除剂。
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公开(公告)号：EP0769300A3
公开(公告)日：1999-11-24
申请号：EP96307533.8
申请日：1996-10-17
申请人： PFIZER INC.
IPC分类号： A61K45/06
CPC分类号： A61K45/06
摘要： The present invention relates to methods of treating or preventing emesis in mammals, including humans, using an NK-1 antagonist in combination with one or more other active agents selected from (a) a glucocorticoid or corticosteroid, (b) a benzodiazepine, (c) metaclopramide and (d) an intracellular molecular scavenger.
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4.发明公开NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis 失效用于治疗呕吐的NK-1受体拮抗剂和5HT3受体拮抗剂
公开(公告)号：EP0715855A3
公开(公告)日：1999-01-20
申请号：EP95308273.2
申请日：1995-11-20
申请人： PFIZER INC.
发明人： Gonsalves, Susan F.
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , Y10S514/816 , Y10S514/872
摘要： The present invention relates to a method of treating or preventing emesis in a mammal, including a human, by administering to the mammal a 5HT 3 receptor antagonist and an NK-1 receptor antagonist ( e.g. , a substance P receptor antagonist). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a 5HT 3 receptor antagonist and an NK-1 receptor antagonist.
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