公开(公告)号：EP1117643A1

公开(公告)日：2001-07-25

申请号：EP99949272.1

申请日：1999-10-01

申请人： Pliva, Farmaceutska, Industrija, Dionicko Drustvo

发明人： FILIC, Darko ,  DUMIC, Miljenko ,  DANILOVSKI, Aleksandar ,  KLEPIC, Bozena ,  FISTRIC, Ines ,  ORESIC, Marina ,  HORVAT MIKULCIC, Jasna

IPC分类号： C07D213/74

CPC分类号： A61K31/44 ,  C07D213/53 ,  C07D213/71 ,  C07D213/74

摘要： The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.

公开(公告)号：EP1117643B1

公开(公告)日：2004-12-29

申请号：EP99949272.1

申请日：1999-10-01

申请人： Pliva, Farmaceutska, Industrija, Dionicko Drustvo

发明人： FILIC, Darko ,  DUMIC, Miljenko ,  DANILOVSKI, Aleksandar ,  KLEPIC, Bozena ,  FISTRIC, Ines ,  ORESIC, Marina ,  HORVAT MIKULCIC, Jasna

IPC分类号： C07D213/74

CPC分类号： A61K31/44 ,  C07D213/53 ,  C07D213/71 ,  C07D213/74

摘要： The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.