公开(公告)号：EP4035659A1

公开(公告)日：2022-08-03

申请号：EP22151613.1

申请日：2017-11-29

申请人： PureTech LYT, Inc.

发明人： BOLEN, Joseph ,  BONNER, Daniel Kenneth ,  FERREIRA, Lisa V. ,  KRUMOVA, Katerina ,  JANTZ, John ,  MUTAMBA, James Tendai ,  SHYAM, Rishab R.

IPC分类号： A61K9/133 ,  A61K9/127 ,  A61K9/10 ,  A61K9/00 ,  A61K48/00

摘要： The present invention provides exosomes as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within such exosomes, methods of producing such exosomes and compositions thereof, as well as methods of delivering such exosomes and compositions to a specific patient tissue or organ. The present invention also provides methods of treating a disease, disorder, or condition such as cancer, an inflammatory disease, an infectious disease, an allergic disease, or an autoimmune disease, comprising administering to a patient in need thereof a provided therapeutic-loaded exosome or a pharmaceutical composition thereof.