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1.发明授权
公开(公告)号：EP1028774B1
公开(公告)日：2004-08-11
申请号：EP98957728.3
申请日：1998-11-07
发明人： KOHN, Joachim, B. , BOLIKAL, Durgadas , BRODE, George, L. , ERTEL, Sylvie, I. , GUAN, Shuiyun , KEMNITZER, John, E.
CPC分类号： A61L27/58 , A61K9/204 , A61K38/00 , A61L17/10 , A61L27/18 , A61L31/06 , A61L31/148 , C07K14/001 , C08G63/672 , C08G63/6856 , C08G63/6858 , C08G64/045 , C08G64/12 , C08G64/1641 , C08G64/183 , C08G69/10 , C08G69/44 , C08L69/00
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2.发明公开
公开(公告)号：EP1028774A1
公开(公告)日：2000-08-23
申请号：EP98957728.3
申请日：1998-11-07
发明人： KOHN, Joachim, B. , BOLIKAL, Durgadas , BRODE, George, L. , ERTEL, Sylvie, I. , GUAN, Shuiyun , KEMNITZER, John, E.
IPC分类号： A61M31/00
CPC分类号： A61L27/58 , A61K9/204 , A61K38/00 , A61L17/10 , A61L27/18 , A61L31/06 , A61L31/148 , C07K14/001 , C08G63/672 , C08G63/6856 , C08G63/6858 , C08G64/045 , C08G64/12 , C08G64/1641 , C08G64/183 , C08G69/10 , C08G69/44 , C08L69/00
摘要： A polymer with a hydrolytically labile backbone and having structure (VIII) wherein R9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof; R12 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid ester group selected from straight and branched alkyl and alkylaryl esters containing up to 18 carbon atoms and ester derivatives of biologically and pharmaceutically active compounds covalently bonded thereto, provided that the ester group is not a benzyl group or a group that is removed by hydrogenolysis; each R7 is independently an alkylene group containing up to four carbon atoms; A is selected from: (a) and (b) wherein R8 is selected from saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms; k is between about 5 and about 3,000; and x and f independently range from zero to less than one.
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