公开(公告)号：EP3478330A1

公开(公告)日：2019-05-08

申请号：EP17737237.2

申请日：2017-06-29

申请人： Realco ,  Symbiose Biomaterials

发明人： BLACKMAN, Gordon ,  FASTREZ, Sébastien ,  GATHY, Camille ,  BEBRONE, Carine ,  VANDEGAART, Hélène ,  DUYSENS, Guérin

IPC分类号： A61L12/08 ,  C11D3/386 ,  C11D3/48 ,  C11D17/04

公开(公告)号：EP3335044A1

公开(公告)日：2018-06-20

申请号：EP16753876.8

申请日：2016-08-11

申请人： Symbiose Biomaterials SA

发明人： BEBRONE, Carine ,  VANDEGAART, Hélène ,  NICAISE, Dominique

IPC分类号： G01N33/53 ,  B01D39/00 ,  C07K7/00

摘要： The invention relates to a method for the detection of asbestos in a sample, comprising the steps of: (a) contacting a sample with one or more asbestos-binding peptides having from 5 to about 50 amino acids, comprising an amino acid sequence selected from D A V P I F M (SEQ ID NO:1), E L A N Q S L (SEQ ID NO:2), T Y A L P T T (SEQ ID NO:3), A D I R H I K (SEQ ID NO:4), L E T V V S S (SEQ ID NO:5) Q V N G L G E R S Q Q M (SEQ ID NO:6), and/or one or more asbestos-binding peptides having from 5 to about 50 amino acids comprising a motif selected from S/T X S/T or S/T X X S/T, wherein S/T means either serine or threonine amino acid in the sequence and X can be any of the proteinogenic amino acids, and in the motif S/T X X S/T, both X are the same or a different proteinogenic amino acid (b) detecting the presence of peptides bound to asbestos fibers. The invention further relates to asbestos-binding peptides, fused asbestos-binding peptides and to a kit for carrying out the above detection method.