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1.发明授权PCTD plasmid isolated from chlamydia trachomatis serotype D, its genes and proteins encoded by them; recombinant plasmids for the expression of said genes in heterologous systems as fused recombinant proteins, preparation of said recombinant proteins and their use in the formulation of vaccines and/or dianostics 失效从沙眼衣原体血清型D此分离PCTD质粒，基因和蛋白质由其编码，重组质粒对他们的基因如在keterologen系统融合蛋白的表达，以及它们作为疫苗和/或Diagnostiekformulierung使用
公开(公告)号：EP0499681B1
公开(公告)日：1999-06-09
申请号：EP91106110.9
申请日：1991-04-17
申请人： SCLAVO S.p.A.
IPC分类号： C12N15/30 , A61K39/118 , G01N33/569 , C07K14/295
CPC分类号： C07K14/295 , A61K38/00 , A61K39/00 , C07K16/125 , C07K2319/00 , C07K2319/75 , C12N15/74
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2.发明公开PCTD plasmid isolated form chlamydia trachomatis serotype D, its genes and proteins encoded by them; recombinant plasmids for the expression of said genes in heterologous systems as fused recombinant proteins, preparation of said recombinant proteins and their use in the formulation of vaccins and/or gianostics 失效从沙眼衣原体血清型D此分离PCTD质粒，基因和蛋白质由其编码，重组质粒对他们的基因如在keterologen系统融合蛋白的表达，以及它们作为疫苗和/或Diagnostiekformulierung使用。
公开(公告)号：EP0499681A1
公开(公告)日：1992-08-26
申请号：EP91106110.9
申请日：1991-04-17
申请人： SCLAVO S.p.A.
IPC分类号： C12N15/30 , A61K39/118 , G01N33/569 , C07K15/00
CPC分类号： C07K14/295 , A61K38/00 , A61K39/00 , C07K16/125 , C07K2319/00 , C07K2319/75 , C12N15/74
摘要： A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E.coli further described.
摘要翻译： 从沙眼衣原体分离的质粒进行了说明，其包含编码在疫苗或用于确定性采矿诊断测试的制剂有用的蛋白质8个基因的细菌或期间沙眼衣原体感染产生的特异性抗体; 特别是在重组融合蛋白是MS2 pgp3D描述了包含由PCT编码并以人感染过程的免疫原性多肽性序列。 还描述一种用于在大肠杆菌中制备所述蛋白质的方法。
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