公开(公告)号：EP1806342A1

公开(公告)日：2007-07-11

申请号：EP05800158.7

申请日：2005-10-28

申请人： SHIONOGI & CO., LTD.

发明人： ISHIZUKA, Natsuki, Shionogi & Co., Ltd. ,  SASATANI, Takashi, Shionogi & Co., Ltd. ,  HIRAMATSU, Yoshiharu, Shionogi & Co., Ltd. ,  INAGAKI, Masanao, Shionogi & Co., Ltd. ,  ODAN, Masahide, Shionogi & Co., Ltd. ,  HASHIZUME, Hiroshi, Shionogi & Co., Ltd. ,  MITSUMORI, Susumu, Shionogi & Co., Ltd. ,  FUJII, Yasuhiko, Shionogi & Co., Ltd. ,  FUKUI, Yoshikazu, Shionogi & Co., Ltd. ,  WATANABE, Hideaki, Shionogi & Co., Ltd. ,  SATO, Jun, Shionogi & Co., Ltd.

IPC分类号： C07D213/82

CPC分类号： C07D213/82

摘要： The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I):

wherein R 1 is optionally substituted C1-C8 alkyl and the like; R 2 is C1-C6 alkyl; R 3 is C1-C6 alkyl and the like; or R 2 and R 3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R 4 is hydrogen and the like; G is a group selected from the groups shown by the formula an the like:

wherein R 5 is hydrogen and the like; X 1 is a single bond and the like; X 2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of -O-, or -N(R 6 )-, wherein R 6 is hydrogen and the like, and the like; X 3 is a single bond and the like;
a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

摘要翻译： 本发明提供对大麻素受体具有激动作用的化合物，其由式（I）表示：其中R 1为任选取代的C 1 -C 8烷基等; R 2是C 1 -C 6烷基; R 3是C 1 -C 6烷基等; 或R 2和R 3可以一起形成任选取代的5至10元非芳族碳环; R 4是氢等; G为选自下式的基团：其中R 5为氢等; X 1是单键等; X 2是可以被一个或两个-O-或-N（R 6） - 基团取代的任选取代的C 1 -C 8亚烷基，其中R 6是氢等; X 3是单键等; 其药学上可接受的盐或溶剂合物，以及药物组合物，特应性皮炎治疗剂和抗瘙痒剂，特别是用于口服使用和外用的抗瘙痒剂，其各自含有所述化合物作为活性成分。

公开(公告)号：EP1806342B1

公开(公告)日：2013-04-17

申请号：EP05800158.7

申请日：2005-10-28

申请人： SHIONOGI & CO., LTD.

发明人： ISHIZUKA, Natsuki, Shionogi & Co., Ltd. ,  SASATANI, Takashi, Shionogi & Co., Ltd. ,  HIRAMATSU, Yoshiharu, Shionogi & Co., Ltd. ,  INAGAKI, Masanao, Shionogi & Co., Ltd. ,  ODAN, Masahide, Shionogi & Co., Ltd. ,  HASHIZUME, Hiroshi, Shionogi & Co., Ltd. ,  MITSUMORI, Susumu, Shionogi & Co., Ltd. ,  FUJII, Yasuhiko, Shionogi & Co., Ltd. ,  FUKUI, Yoshikazu, Shionogi & Co., Ltd. ,  WATANABE, Hideaki, Shionogi & Co., Ltd. ,  SATO, Jun, Shionogi & Co., Ltd.

IPC分类号： C07D213/82

CPC分类号： C07D213/82