公开(公告)号：EP0267378B1

公开(公告)日：1992-11-04

申请号：EP87112029.1

申请日：1987-08-19

申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

发明人： Kondo, Eiji ,  Hayashi, Yoshiyuki ,  Konishi, Takao ,  Hattori, Teruo ,  Shoji, Junichi

IPC分类号： A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/34 ,  A61K31/26 ,  A61K31/335

CPC分类号： A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/26 ,  A61K31/335 ,  A61K31/34

公开(公告)号：EP0267378A2

公开(公告)日：1988-05-18

申请号：EP87112029.1

申请日：1987-08-19

申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

发明人： Kondo, Eiji ,  Hayashi, Yoshiyuki ,  Konishi, Takao ,  Hattori, Teruo ,  Shoji, Junichi

IPC分类号： A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/34 ,  A61K31/26 ,  A61K31/335

CPC分类号： A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/26 ,  A61K31/335 ,  A61K31/34

摘要： An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula;
(wherein R₁ is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-­methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R₂ is hydrogen, halogen, hydroxy, alkyl or alkoxy)
and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.

摘要翻译： 一种抗支原体剂，其包含由式表示的扑普龙，其衍生物; （其中R1是羟基，脂族酰氧基，芳基酰氧基，芳磺酰氧基，羧基烷氧基或其酯，苯甲酰基烷氧基，烯氧基，1,3-二氢-3-氧代-1-异苯并呋喃基氧基，（2-氧代-5-甲基-1， 3-二氧杂环戊烯-4-基）甲氧基或硫氰酸酯，R 2是氢，卤素，羟基，烷基或烷氧基）及其盐作为活性成分，其在体外和体内都特别有效地抵抗泰乐菌素抗性支原体，并且是 有效地用于治疗由此引起的疾病。

公开(公告)号：EP0267378A3

公开(公告)日：1990-04-25

申请号：EP87112029.1

申请日：1987-08-19

申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

发明人： Kondo, Eiji ,  Hayashi, Yoshiyuki ,  Konishi, Takao ,  Hattori, Teruo ,  Shoji, Junichi

IPC分类号： A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/34 ,  A61K31/26 ,  A61K31/335

CPC分类号： A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/26 ,  A61K31/335 ,  A61K31/34

摘要： An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula;
(wherein R₁ is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-­methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R₂ is hydrogen, halogen, hydroxy, alkyl or alkoxy)
and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.