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1.发明授权AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES 有权氨基衍生物B-HOMOANDROSTANEN和B-HETEROANDROSTANEN
公开(公告)号：EP2032593B1
公开(公告)日：2011-02-02
申请号：EP07729767.9
申请日：2007-05-31
发明人： CERRI, Alberto , MORO, Barbara , TORRI, Maco , CARZANA, Giulio , BIANCHI, Giuseppe , FERRANDI, Mara , FERRARI, Patrizia , ZAPPAVIGNA, Maria Pia , BANFI, Leonardo , GIACALONE, Giuseppe
IPC分类号： C07J3/00 , C07J63/00 , A61K31/58 , A61K31/565 , A61K31/566 , A61P9/04 , A61P9/06
CPC分类号： C07J73/005 , C07J63/004 , C07J73/003
摘要： New aminoalkoxyimino derivatives at position 3 of substituted B- homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
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2.发明公开AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES 有权B-HOMOANDROSTANES和B-HETEROANDROSTANES的氨基衍生物
公开(公告)号：EP2032593A1
公开(公告)日：2009-03-11
申请号：EP07729767.9
申请日：2007-05-31
发明人： CERRI, Alberto , MORO, Barbara , TORRI, Maco , CARZANA, Giulio , BIANCHI, Giuseppe , FERRANDI, Mara , FERRARI, Patrizia , ZAPPAVIGNA, Maria Pia , BANFI, Leonardo , GIACALONE, Giuseppe
IPC分类号： C07J3/00 , C07J63/00 , A61K31/58 , A61K31/565 , A61K31/566 , A61P9/04 , A61P9/06
CPC分类号： C07J73/005 , C07J63/004 , C07J73/003
摘要： New aminoalkoxyimino derivatives at position 3 of substituted B- homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
摘要翻译： 取代的B-homoandrostanes和B-heteroandrostanes的3位新氨基烷氧基亚胺基衍生物及其制备方法，以及含有它们的药物组合物用于治疗心血管疾病如心力衰竭和高血压。 特别是描述了具有通式（I）的化合物，其中基团具有在本申请中详细描述的含义。
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3.发明授权AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 有权氨基酸衍生物的雄甾烷和ANDROSTENEN AS药物预防心脏病CYCLE
公开(公告)号：EP2004668B1
公开(公告)日：2013-03-13
申请号：EP07727992.5
申请日：2007-04-11
发明人： CERRI, Alberto , TORRI, Marco , ARMAROLI, Silvia , BANFI, Leonardo , BIANCHI, Giuseppe , CARZANA, Giulio , FERRARI, Patrizia , MICHELETTI, Rosamaria , SPUTORE, Simona , ZAPPAVIGNA, Maria Pia
IPC分类号： C07J41/00 , C07J43/00 , A61K31/58 , A61K31/565 , A61P9/04
CPC分类号： C07J41/0038 , C07J41/0016 , C07J43/003
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4.发明公开AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 有权氨基酸衍生物的雄甾烷和ANDROSTENEN AS药物预防心脏病CYCLE
公开(公告)号：EP2004668A2
公开(公告)日：2008-12-24
申请号：EP07727992.5
申请日：2007-04-11
发明人： CERRI, Alberto , TORRI, Marco , ARMAROLI, Silvia , BANFI, Leonardo , BIANCHI, Giuseppe , CARZANA, Giulio , FERRARI, Patrizia , MICHELETTI, Rosamaria , SPUTORE, Simona , ZAPPAVIGNA, Maria Pia
IPC分类号： C07J41/00 , C07J43/00 , A61K31/58 , A61K31/565 , A61P9/04
CPC分类号： C07J41/0038 , C07J41/0016 , C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
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