公开(公告)号：EP0969002B1

公开(公告)日：2003-08-27

申请号：EP99305010.3

申请日：1999-06-25

申请人： SUMIKA FINE CHEMICALS Co., Ltd.

发明人： Yamazaki, Shigeya, Sumika Fine Chemicals Co. Ltd ,  Ishibashi, Taro, Sumika Fine Chemicals Co. Ltd ,  Kawada, Yoshihiro, Sumika Fine Chemicals Co. Ltd ,  Yumoto, Hiroyuki, Sumika Fine Chemicals Co. Ltd ,  Yoshikawa, Taichi, Sumika Fine Chemicals Co. Ltd ,  Igi, Masami, Sumika Fine Chemicals Co. Ltd

IPC分类号： C07D211/22

CPC分类号： C07D211/22

公开(公告)号：EP0969002A1

公开(公告)日：2000-01-05

申请号：EP99305010.3

申请日：1999-06-25

申请人： SUMIKA FINE CHEMICALS Co., Ltd.

发明人： Yamazaki, Shigeya, Sumika Fine Chemicals Co. Ltd ,  Ishibashi, Taro, Sumika Fine Chemicals Co. Ltd ,  Kawada, Yoshihiro, Sumika Fine Chemicals Co. Ltd ,  Yumoto, Hiroyuki, Sumika Fine Chemicals Co. Ltd ,  Yoshikawa, Taichi, Sumika Fine Chemicals Co. Ltd ,  Igi, Masami, Sumika Fine Chemicals Co. Ltd

IPC分类号： C07D211/22

CPC分类号： C07D211/22

摘要： An L-tartrate of a trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound, represented by the formula (I):
wherein R 1 is hydrogen atom, a substituted or unsubstituted, linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group having 7 to 12 carbon atoms. The L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound can be suitably used as an intermediate for pharmaceuticals such as paroxetine which is useful, for example, as an antidepressant.

摘要翻译： 由式（I）表示的反 - （ - ） - 4-（4-氟苯基）-3-羟甲基哌啶化合物的L-酒石酸盐：其中R 1是氢原子，取代或未取代的， 具有1至6个碳原子的直链或支链烷基或具有7至12个碳原子的芳烷基。 反式 - （ - ） - 4-（4-氟苯基）-3-羟甲基哌啶化合物的L-酒石酸盐可以适当地用作药物例如帕罗西汀的中间体，其可用作例如抗抑郁药。