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    AMORPHOUS TELITHROMYCIN COMPOUND
    3.
    发明公开
    AMORPHOUS TELITHROMYCIN COMPOUND 审中-公开
    稳定的无定形泰利CONNECTION

    公开(公告)号：EP1973924A1

    公开(公告)日：2008-10-01

    申请号：EP07700180.8

    申请日：2007-01-04

    申请人： SANDOZ AG

    发明人： LUDESCHER, Johannes ,  GRIESSER, Ulrich ,  LANGES, Christoph

    IPC分类号： C07H17/08 ,  A61K31/7048

    CPC分类号： C07H17/08

    摘要： The present invention relates to stable amorphous 3-De[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L- ribohexopyranosy l)oxy]- 1 1 , 12-dideoxy-6-O-methy 1-3-oxo- 12,11 -[oxycarbonyl[[4-[4-(3-pyridinyl)- 1 H- imidazol-l-yl]butyl]imino]]erythromycin (telithromycin), methods for the preparation thereof, the use of stable amorphous telithromycin in the treatment of bacterial infections and to pharmaceutical compositions comprising stable amorphous telithromycin.

    NOVEL POLYMORPHS OF APREPITANT AND PROCESSES FOR PREPARATION
    7.
    发明公开
    NOVEL POLYMORPHS OF APREPITANT AND PROCESSES FOR PREPARATION 审中-公开
    阿瑞和方法的新多晶型

    公开(公告)号：EP2129671A2

    公开(公告)日：2009-12-09

    申请号：EP08717054.4

    申请日：2008-02-22

    申请人： Sandoz AG

    发明人： LUDESCHER, Johannes ,  WIESER, Josef ,  PICHLER, Arthur ,  GRIESSER, Ulrich ,  BRAUN, Doris

    IPC分类号： C07D413/06 ,  A61K31/5377 ,  A61P9/08

    CPC分类号： C07D413/06

    摘要： Novel polymorph form III of Aprepitant and a method for preparation of novel form III is disclosed. New processes for the preparation of Aprepitant form II are disclosed. The processes involve transformation of form III to form II by heating in decalin and the precipitation of form II from a solvent or solvent mixture by cooling and/or addition of addition of seed crystals or an anti solvent. Solid dispersions containing Aprepitant form II in a suitable carrier are disclosed. A process for the preparation of the solid dispersion by evaporation of a solution of Aprepitant and the carrier in a suitable solvent is disclosed. Stable Aprepitant form II is disclosed. Further pharmaceutical compositions containing Aprepitant form II, III or solid dispersions containing Aprepitant form II in a suitable carrier are disclosed. A methanol solvate of Aprepitant is disclosed.

    CRYSTALLINE FORM OF CINACALCET
    8.
    发明公开
    CRYSTALLINE FORM OF CINACALCET 审中-公开
    西那卡塞晶型

    公开(公告)号：EP2064173A1

    公开(公告)日：2009-06-03

    申请号：EP07785846.2

    申请日：2007-06-25

    申请人： Sandoz AG

    发明人： LUDESCHER, Johannes ,  GRIESSER, Ulrich ,  BRAUN, Doris ,  WIESER, Josef

    IPC分类号： C07C211/30 ,  A61K31/135

    CPC分类号： C07C211/30

    摘要： The present invention relates to the polymorph form II of Cinacalcet hydrochloride, methods for the preparation of pure form II of Cinacalcet hydrochloride, and pharmaceutical compositions comprising the new polymorphic form in an pharmaceutically effective amount The present invention also provides novel solvates of Cinacalcet hydrochloride, methods for the preparation of these solvates, the use of these novel solvates for the preparation of pure Cinacalcet hydrochloride, the use of these novel solvates for the preparation of polymorphic form II of Cinacalcet hydrochloride and pharmaceutical compositions comprising the acetic acid solvate of Cinacalcet hydrochloride.

    POLYMORPHS OF FEBUXOSTAT
    9.
    发明公开
    POLYMORPHS OF FEBUXOSTAT 审中-公开
    POLYMORPHE VON FEBUXOSTAT

    公开(公告)号：EP2977372A1

    公开(公告)日：2016-01-27

    申请号：EP15181097.5

    申请日：2011-06-24

    申请人： SANDOZ AG

    发明人： HOTTER, Andreas ,  GRIESSER, Ulrich ,  ADAMER, Verena ,  LANGES, Christoph

    IPC分类号： C07D277/56 ,  A61K31/425 ,  A61P19/06

    CPC分类号： C07D277/56

    摘要： The present invention relates to crystalline form I of Febuxostat as well as to pharmaceutical compositions comprising crystalline form I as an active pharmaceutical ingredient. Furthermore the present invention relates to a further polymorphic form of Febuxostat designated as form II and to a novel solvate of Febuxostat. The present invention also relates to methods of making crystalline form I, form II and the novel solvate of Febuxostat.

    摘要翻译： 本发明涉及非甾体酮的结晶形式I以及包含结晶形式I作为活性药物成分的药物组合物。 此外，本发明涉及另一种指定为形式II的非诺沙星的多晶型物，还涉及一种新颖的非索非司坦溶剂合物。 本发明还涉及制备结晶形式I，形式II和新戊酸钠的新溶剂化物的方法。