公开(公告)号：EP2443134A2

公开(公告)日：2012-04-25

申请号：EP10727310.4

申请日：2010-06-15

申请人： Schering Corporation

发明人： BIJU, Purakkattle, J. ,  BERLIN, Michael, Y. ,  LIM, Yeon-Hee ,  BITAR, Rema, D. ,  MCCORMICK, Kevin, D. ,  ASLANIAN, Robert, G. ,  LEE, Yoon Joo ,  ZHENG, Junying ,  HUANG, Ying ,  WON, Walter

IPC分类号： C07J71/00 ,  A61K31/59 ,  A61P5/44

CPC分类号： C07J71/0047 ,  C07J71/0063

摘要： The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: Formula (I) wherein L, R
1 , R
2 , R
3 , R
4 , R
5 , and R
6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas (H-A), (II-A1 ), (II-A2), (II-A2.1 ), (ll-A-2.2), (ll-A-2.3), (II-A4), (H-B), (H-C), (III), (IV), (V), (Vl), as described herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.