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    MESOTHELIOMA BIOMARKERS AND USES THEREOF
    1.
    发明公开
    MESOTHELIOMA BIOMARKERS AND USES THEREOF 审中-公开
    对于间皮瘤生物标记及其用途

    公开(公告)号：EP3029153A3

    公开(公告)日：2016-07-13

    申请号：EP15189622.2

    申请日：2011-09-27

    申请人： Somalogic, Inc.

    发明人： OSTROFF, Rachel M. ,  STEWART, Alex A. E. ,  WILLIAMS, Stephen Alaric ,  BRODY, Edward N. ,  NIKRAD, Malti ,  RIEL-MEHAN, Michael

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2800/50

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and mesothelioma specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or mesothelioma specifically. In another aspect, methods are provided for diagnosing mesothelioma in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having mesothelioma, or the likelihood of the individual having mesothelioma is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.

    MESOTHELIOMA BIOMARKERS AND USES THEREOF
    2.
    发明授权
    MESOTHELIOMA BIOMARKERS AND USES THEREOF 有权

    公开(公告)号：EP3029153B1

    公开(公告)日：2018-08-01

    申请号：EP15189622.2

    申请日：2011-09-27

    申请人： Somalogic, Inc.

    发明人： OSTROFF, Rachel M. ,  STEWART, Alex A. E. ,  WILLIAMS, Stephen Alaric ,  BRODY, Edward N. ,  NIKRAD, Malti ,  RIEL-MEHAN, Michael

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2800/50

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and mesothelioma specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or mesothelioma specifically. In another aspect, methods are provided for diagnosing mesothelioma in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having mesothelioma, or the likelihood of the individual having mesothelioma is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.

    NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND NONALCOHOLIC STEATOHEPATITIS (NASH) BIOMARKERS AND USES THEREOF
    3.
    发明公开
    NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND NONALCOHOLIC STEATOHEPATITIS (NASH) BIOMARKERS AND USES THEREOF 有权
    非酒石酸脂肪肝（NAFLD）和非酒石酸性肝炎（NASH）生物标志物及其用途

    公开(公告)号：EP3296747A1

    公开(公告)日：2018-03-21

    申请号：EP17197260.7

    申请日：2014-03-10

    申请人： Somalogic, Inc.

    发明人： NIKRAD, Malti ,  FIELD, Stuart G. ,  WILLIAMS, Stephen Alaric

    IPC分类号： G01N33/68

    摘要： Methods, compositions, and kits for determining whether a subject has non-alcoholic fatty liver disease (NAFLD) are provided. Methods, compositions, and kits for determining whether a subject has non-alcoholic steatosis are also provided. Methods, compositions, and kits for determining whether a subject has non-alcoholic steatohepatitis (NASH) are also provided.

    摘要翻译： 提供了用于确定受试者是否患有非酒精性脂肪肝病（NAFLD）的方法，组合物和试剂盒。 还提供了用于确定受试者是否具有非酒精性脂肪变性的方法，组合物和试剂盒。 还提供了用于确定受试者是否患有非酒精性脂肪性肝炎（NASH）的方法，组合物和试剂盒。

    MESOTHELIOMA BIOMARKERS AND USES THEREOF
    5.
    发明公开
    MESOTHELIOMA BIOMARKERS AND USES THEREOF 审中-公开
    对于间皮瘤生物标记及其用途

    公开(公告)号：EP2622104A2

    公开(公告)日：2013-08-07

    申请号：EP11831270.1

    申请日：2011-09-27

    申请人： Somalogic, Inc.

    发明人： OSTROFF, Rachel, M. ,  STEWART, Alex, A., E. ,  WILLIAMS, Stephen, Alaric ,  BRODY, Edward, N. ,  NIKRAD, Malti ,  RIEL-MEHAN, Michael

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2800/50

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and mesothelioma specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or mesothelioma specifically. In another aspect, methods are provided for diagnosing mesothelioma in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having mesothelioma, or the likelihood of the individual having mesothelioma is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.

    MESOTHELIOMA BIOMARKERS AND USES THEREOF
    9.
    发明公开
    MESOTHELIOMA BIOMARKERS AND USES THEREOF 审中-公开
    MESOTHELIOMA BIOMARKERS及其用途

    公开(公告)号：EP3029153A2

    公开(公告)日：2016-06-08

    申请号：EP15189622.2

    申请日：2011-09-27

    申请人： Somalogic, Inc.

    发明人： OSTROFF, Rachel M. ,  STEWART, Alex A. E. ,  WILLIAMS, Stephen Alaric ,  BRODY, Edward N. ,  NIKRAD, Malti ,  RIEL-MEHAN, Michael

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2800/50

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and mesothelioma specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or mesothelioma specifically. In another aspect, methods are provided for diagnosing mesothelioma in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having mesothelioma, or the likelihood of the individual having mesothelioma is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本公开内容包括用于特异性地检测和诊断癌症和间皮瘤的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，本公开内容提供了可以单独或以各种组合使用的生物标志物，以特异性地诊断癌症或间皮瘤。 另一方面，提供了用于诊断个体间皮瘤的方法，其中所述方法包括在来自个体的生物样品中检测对应于选自表1中提供的生物标志物组的至少一种生物标志物的至少一种生物标志物值， 其中所述个体被分类为具有间皮瘤，或基于所述至少一个生物标志物值确定所述个体具有间皮瘤的可能性。 在另一方面，提供了用于诊断个体中的癌症的方法，其中所述方法包括在来自个体的生物样品中检测对应于选自表中提供的生物标志物组中的至少一种生物标志物的至少一种生物标志物值 19，其中基于所述至少一个生物标志物值，所述个体一般被分类为患有癌症，或所述个体患有癌症的可能性被确定。