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公开(公告)号：EP1280775A1
公开(公告)日：2003-02-05
申请号：EP00927978.7
申请日：2000-05-12
申请人： Synthon B.V.
IPC分类号： C07D211/22
CPC分类号： C07D211/22
摘要： A process for purifying a compound of formula (1) from a des-fluoroimpurity of formula (7) wherein R in both compounds (1) and (7) represents a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group, an alkoxycarbonyl group or an aryloxycarbonyl group, which comprises the step of reacting a compound of formula (1) with toluene sulfonic acid.
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公开(公告)号：EP1286965A1
公开(公告)日：2003-03-05
申请号：EP00927979.5
申请日：2000-05-12
申请人： Synthon B.V.
IPC分类号： C07D211/22 , C07D405/12
CPC分类号： C07D211/22 , C07D405/12
摘要： Process for providing a compound of formula (6), a hydrate, solvate, and/or salt thereof, for example a pharmaceutically acceptable acid addition salt, comprising the step of reacting a compound of formula (1), with a tosyl moiety, providing compound.
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公开(公告)号：EP1286965B1
公开(公告)日：2004-01-14
申请号：EP00927979.5
申请日：2000-05-12
申请人： Synthon B.V.
IPC分类号： C07D211/22 , C07D405/12
CPC分类号： C07D211/22 , C07D405/12
摘要： Process for providing a compound of formula (6), a hydrate, solvate, and/or salt thereof, for example a pharmaceutically acceptable acid addition salt, comprising the step of reacting a compound of formula (1), with a tosyl moiety, providing compound.
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公开(公告)号：EP1560814A1
公开(公告)日：2005-08-10
申请号：EP03779870.9
申请日：2003-11-07
申请人： Synthon B.V.
发明人： SLANINA, Pavel , BARTL, Jiri
IPC分类号： C07D211/58 , C07D471/04
CPC分类号： C07D471/04 , C07D211/58
摘要： The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of Formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.
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