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公开(公告)号：EP0645374B1
公开(公告)日：1996-11-20
申请号：EP93909405.8
申请日：1993-04-21
发明人： YOSHIKAWA, Kensei Taisho Pharmaceutical Co., Ltd. , SAITO, Shuji Taisho Pharmaceutical Co., Ltd. , SHIMAZAKI, Yohichi Taisho Pharmaceutical Co., Ltd. , KASHIWA, Mariko Taisho Pharmaceutical Co., Ltd. , HATAYAMA, Katsuo Taisho Pharmaceutical Co., Ltd.
IPC分类号： C07C311/08 , A61K31/18
CPC分类号： C07C311/08
摘要： A 5-amino-2-phenoxysulfonanilide compound represented by formula (I) and a salt thereof, having excellent anti-inflammatory, antipyretic, analgesic and antirheumatic effects, thus being useful as anti-inflammatory, antipyretic, analgesic and antirheumatic agents.
摘要翻译： 由式（I）表示的5-氨基-2-苯氧基磺酰苯胺化合物及其盐具有优异的抗炎，解热，镇痛和抗风湿作用，因此可用作抗炎剂，解热剂，镇痛剂和抗风湿剂。
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公开(公告)号：EP0685461A1
公开(公告)日：1995-12-06
申请号：EP94907051.0
申请日：1994-02-16
发明人： YOSHIKAWA, Kensei Taisho Pharmaceutical Co., Ltd. , SAITO, Shiuji Taisho Pharmaceutical Co., Ltd. , SHIMAZAKI, Yohichi Taisho Pharmaceutical Co., Ltd. , KASHIWA, Mariko Taisho Pharmaceutical Co., Ltd. , HATAYAMA, Katsuo Taisho Pharmaceutical Co., Ltd.
IPC分类号： C07C311/08 , C07D295/15 , A61K31/18
CPC分类号： C07D295/15 , C07C311/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： An object of the invention is to provide a drug which is reduced in the side effects such as digestive tract disorder, has such a high safety as to permit long-term administration, and has anti-inflammatory, antipyretic, analgesic and and antiallergic activities. The drug comprises a compound represented by general formula (I) or a salt thereof, wherein R¹ represents phenyl, halophenyl or C₃-C₈ cycloalkyl; R² represents hydrogen or C₁-C₅ alkyl; and R³ represents hydrogen, C₁-C₇ alkyl, C₃-C₈ cycloalkyl, C₃-C₅ alkenyl or benzyl; or alternatively R² and R³ are combined together to represents a 5- to 7- membered heterocyclic group in combination with the nitrogen atom to which they are bonded.
摘要翻译： 本发明的目的在于提供消化道障碍等副作用降低，长期给药安全性高，具有抗炎，解热，镇痛，抗过敏等作用的药物。 该药物包含通式（I）代表的化合物或其盐，其中R 1代表苯基，卤代苯基或C 3 -C 8环烷基; R 2代表氢或C 1 -C 5烷基; 和R 3代表氢，C 1 -C 8烷基，C 3 -C 8环烷基，C 3 -C 5链烯基或苄基; 或者也可以将R 2和R 3结合在一起表示与它们键合的氮原子结合的5至7元杂环基。
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公开(公告)号：EP0645374A1
公开(公告)日：1995-03-29
申请号：EP93909405.8
申请日：1993-04-21
发明人： YOSHIKAWA, Kensei Taisho Pharmaceutical Co., Ltd. , SAITO, Shuji Taisho Pharmaceutical Co., Ltd. , SHIMAZAKI, Yohichi Taisho Pharmaceutical Co., Ltd. , KASHIWA, Mariko Taisho Pharmaceutical Co., Ltd. , HATAYAMA, Katsuo Taisho Pharmaceutical Co., Ltd.
IPC分类号： C07C311/08 , A61K31/18
CPC分类号： C07C311/08
摘要： A 5-amino-2-phenoxysulfonanilide compound represented by formula (I) and a salt thereof, having excellent anti-inflammatory, antipyretic, analgesic and antirheumatic effects, thus being useful as anti-inflammatory, antipyretic, analgesic and antirheumatic agents.
摘要翻译： 由式（I）表示的5-氨基-2-苯氧基磺酰苯胺化合物及其盐具有优异的抗炎，解热，镇痛和抗风湿作用，因此可用作抗炎，解热，镇痛和抗风湿剂。
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