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公开(公告)号：EP0508334B1
公开(公告)日：1998-01-07
申请号：EP92105857.4
申请日：1992-04-04
发明人： Sugiyama, Naoki, c/o The Green , Akaboshi, Fumihiko, c/o The Green , Yakumaru, Haruko, c/o The Green , Gotoh, Tomokazu, c/o The Green , Sugiura, Masanori, c/o The Green , Kuwahara, Shigeki, c/o The Green , Kajii, Masahiko, c/o The Green , Tanaka, Yoshiko, c/o The Green , Kondoh, Takao, c/o The Green , Fukuya, Chikara, c/o The Green
IPC分类号： C07D295/13 , C07D295/125 , A61K31/445 , C07D295/26 , C07D213/38 , C07C217/10 , C07C217/76 , C07C215/80 , C07D213/74 , C07D279/24 , C07D211/22 , C07D211/46
CPC分类号： C07D213/64 , C07C215/80 , C07C217/76 , C07D211/22 , C07D211/46 , C07D213/74 , C07D279/24 , C07D295/13 , C07D295/135 , Y02P20/55
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公开(公告)号：EP0508334A3
公开(公告)日：1993-07-21
申请号：EP92105857.4
申请日：1992-04-04
发明人： Sugiyama, Naoki, c/o The Green , Akaboshi, Fumihiko, c/o The Green , Yakumaru, Haruko, c/o The Green , Gotoh, Tomokazu, c/o The Green , Sugiura, Masanori, c/o The Green , Kuwahara, Shigeki, c/o The Green , Kajii, Masahiko, c/o The Green , Tanaka, Yoshiko, c/o The Green , Kondoh, Takao, c/o The Green , Fukuya, Chikara, c/o The Green
IPC分类号： C07D295/13 , C07D295/125 , A61K31/445 , C07D295/26 , C07D213/38 , C07C217/10 , C07C217/76 , C07C215/80 , C07D213/74 , C07D279/24 , C07D211/22 , C07D211/46
CPC分类号： C07D213/64 , C07C215/80 , C07C217/76 , C07D211/22 , C07D211/46 , C07D213/74 , C07D279/24 , C07D295/13 , C07D295/135 , Y02P20/55
摘要： Aminophenol derivatives of the following formula (I)
wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R⁸ is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.-
3.发明公开Novel aminophenol derivatives and pharmaceutical compositions thereof 失效Neue Aminophenolderivate und diese enthaltende pharmazeutische Zusammensetzungen。
公开(公告)号：EP0508334A2
公开(公告)日：1992-10-14
申请号：EP92105857.4
申请日：1992-04-04
发明人： Sugiyama, Naoki, c/o The Green , Akaboshi, Fumihiko, c/o The Green , Yakumaru, Haruko, c/o The Green , Gotoh, Tomokazu, c/o The Green , Sugiura, Masanori, c/o The Green , Kuwahara, Shigeki, c/o The Green , Kajii, Masahiko, c/o The Green , Tanaka, Yoshiko, c/o The Green , Kondoh, Takao, c/o The Green , Fukuya, Chikara, c/o The Green
IPC分类号： C07D295/13 , C07D295/125 , A61K31/445 , C07D295/26 , C07D213/38 , C07C217/10 , C07C217/76 , C07C215/80 , C07D213/74 , C07D279/24 , C07D211/22 , C07D211/46
CPC分类号： C07D213/64 , C07C215/80 , C07C217/76 , C07D211/22 , C07D211/46 , C07D213/74 , C07D279/24 , C07D295/13 , C07D295/135 , Y02P20/55
摘要： Aminophenol derivatives of the following formula (I)
wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R⁸ is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.摘要翻译： 下式（I）的氨基苯酚衍生物
其中X是氢原子，低级烷基或酚羟基的保护基，Y是氢原子或低级烷基，Z是氢原子，低级烷基，卤原子或三氟甲基，A 是氢原子或低级烷基，t是1〜5的整数，l和m分别是2〜4的整数，E和W是氮原子，F是直接键或氧原子，P和Q各自是氢 原子，卤素原子，低级烷基或低级烷氧基，R 8为氢原子，羟基或羟基保护基，以及它们的药学上可接受的盐。 由于本发明的氨基苯酚衍生物（I）在包括人的哺乳动物动物中具有优异的抗氧化作用和抗炎和抗过敏作用，所以它们作为药物如抗炎药或抗过敏药物是非常有用的。
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