专利检索 ap:("THE UNIVERSITY OF WASHINGTON") AND inv:"MULLINS, James, I." 第 1 页

1.

发明公开
INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA 失效
标题翻译：病毒RNA诱导病毒变异的介绍FAULT CODED核苷类似物

公开(公告)号：EP0948256A1

公开(公告)日：1999-10-13

申请号：EP97913882.0

申请日：1997-10-27

申请人： THE UNIVERSITY OF WASHINGTON

发明人： LOEB, Lawrence, A. , MULLINS, James, I.

IPC分类号： C12N15 , A61K31 , A61K39 , A61K45 , A61P31 , C07H19 , C12N5 , C12N7 , C12Q1

CPC分类号： A61K31/7076 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C12N7/00 , C12N15/102 , C12N2740/16063 , C12N2770/24161 , C12N2770/24261 , C12N2770/24263

摘要： The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the virus results in reduced viability of progeny generations of the virus, thereby inhibiting viral replication. In addition to these methods and related compositions, the invention provides methods and combinatorial chemistry libraries for screening ribonucleoside analogs for mutagenic potential.