公开(公告)号：EP4230624A1

公开(公告)日：2023-08-23

申请号：EP21869736.5

申请日：2021-09-16

申请人： The Asan Foundation ,  Daegu-Gyeongbuk Medical Innovation Foundation ,  University Of Ulsan Foundation For Industry Cooperation

发明人： HWANG, Jung Jin ,  PARK, Sang Eun ,  KIM, Dong Eun ,  HONG, Ji-Ye ,  KIM, Choung-Soo ,  SON, Woo Chan ,  KIM, Shinae ,  KWON, Sugyeong ,  JUNG, Kyungjin ,  KIM, Nayeon ,  KIM, Jina ,  KIM, Kyung-Hee ,  CHIN, Jung Wook ,  CHO, Sung Jin ,  LEE, Sehan ,  CHA, Eunju ,  JOO, Jeongmin ,  HWANG, Ji Sun ,  PARK, Jeong-Eun ,  YU, Ji Hoon ,  HONG, Eunmi ,  PARK, Young-Hoon ,  LEE, Ju-Hee

IPC分类号： C07D401/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/55 ,  A61P35/00 ,  C07D401/12 ,  A23L33/10

摘要： A compound, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof, provided as one aspect of the present invention, exhibits a high inhibitory ability on euchromatic histone-lysine N-methyltransferase 2 (EHMT2), and thus, the compound can be usefully used for the treatment of cancer.

公开(公告)号：EP4159725A1

公开(公告)日：2023-04-05

申请号：EP21812765.2

申请日：2021-04-05

申请人： Daegu-Gyeongbuk Medical Innovation Foundation ,  Trineuro

发明人： SONG, Minsoo ,  IM, Chun Young ,  PARK, Ga Young ,  KO, Eun Bi ,  KANG, Jihee ,  BAE, Seri ,  KIM, Soong-Hyun ,  PARK, Yoojin ,  LEE, Eunhye ,  CHOI, Yujeong ,  CHA, Eunju ,  SEO, Chang Hoon ,  SHIN, Chan Young ,  KWON, Kyoung Ja ,  MABUNGA, Darine Froy ,  PARK, Donghyun ,  HWANG, Hee Jong ,  KIM, Ryeong Eun ,  PAUDEL, Suresh ,  JEON, Se Jin ,  CHO, Kyu Suk

IPC分类号： C07D295/13 ,  A61K31/495 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/18 ,  C07D211/18 ,  C07D401/04 ,  A23L33/10

摘要： Disclosed are a carboxamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.