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公开(公告)号：EP0344955A2
公开(公告)日：1989-12-06
申请号：EP89305153.2
申请日：1989-05-22
发明人： Nudelman, Edward D., The Biomenbrane Institute , Levery, Steven B., The Biomenbrane Institute , Stroud, Mark R., The Biomenbrane Institute , Salyan, Mary Ellen K., The Biomenbrane Institute , Hakomori, Sen-itiroh, The Biomenbrane Institute
摘要： A substantially pure compound comprising an unbranched ceramide polysaccharide type 2 chain having the following structure: wherein Gal represents galactose, GlcNAc represents N -acetylglucoseamine, Fuc represents fucose and Cer represents ceramide. A substantially pure compound comprising an unbranched ceramide polysaccharide type 2 chain having the following structure: wherein Gal represents galactose, GlcNAc represents N -acetylglucoseamine, Fuc represents fucose, Cer represents ceramide and NeuAc represents sialic acid. Antibodies that are specific to portions of the above-described compounds, wherein the portions comprise the internal α1->3 fucosyl residue and/or the terminal sialic acid residue. Immunogens for producing antibodies to the above-described compounds or portions thereof. A method of actively immunizing against tumors that express the above-described compounds.
摘要翻译： 包含具有以下结构的非支链神经酰胺多糖2型链的基本上纯的化合物：其中Gal代表半乳糖，GlcNAc代表N-乙酰葡萄糖胺，Fuc代表岩藻糖并且Cer代表神经酰胺。 包含具有以下结构的非支链神经酰胺多糖2型链的基本上纯的化合物：其中Gal代表半乳糖，GlcNAc代表N-乙酰葡萄糖胺，Fuc代表岩藻糖，Cer代表神经酰胺，NeuAc代表唾液酸。 特异于上述化合物部分的抗体，其中所述部分包含内部α1→3岩藻糖基残基和/或末端唾液酸残基。 用于产生针对上述化合物或其部分的抗体的免疫原。 主动免疫抵抗表达上述化合物的肿瘤的方法。
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公开(公告)号：EP0344955A3
公开(公告)日：1990-05-30
申请号：EP89305153.2
申请日：1989-05-22
发明人： Nudelman, Edward D., The Biomenbrane Institute , Levery, Steven B., The Biomenbrane Institute , Stroud, Mark R., The Biomenbrane Institute , Salyan, Mary Ellen K., The Biomenbrane Institute , Hakomori, Sen-itiroh, The Biomenbrane Institute
摘要： A substantially pure compound comprising an unbranched ceramide polysaccharide type 2 chain having the following structure: wherein Gal represents galactose, GlcNAc represents N -acetylglucoseamine, Fuc represents fucose and Cer represents ceramide. A substantially pure compound comprising an unbranched ceramide polysaccharide type 2 chain having the following structure: wherein Gal represents galactose, GlcNAc represents N -acetylglucoseamine, Fuc represents fucose, Cer represents ceramide and NeuAc represents sialic acid. Antibodies that are specific to portions of the above-described compounds, wherein the portions comprise the internal α1->3 fucosyl residue and/or the terminal sialic acid residue. Immunogens for producing antibodies to the above-described compounds or portions thereof. A method of actively immunizing against tumors that express the above-described compounds.
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